Downstream MMR processing contributes to GAA·TTC repeat expansion
Ed Grabczyk, Anasheh Halabi and Claire Fitzgerald
FASEB J. April 2013 27 (Meeting Abstract Supplement) lb76
Posted: 04-24-2013 - FARA Funded Research

Cardiac remodeling of intercalated discs in Friedreich’s ataxia
Joseph E. Mazurkiewicz, R. Lianne Ramirez and Arnulf H. Koeppen
FASEB J. April 2013 27 (Meeting Abstract Supplement) 1194.8
Posted: 04-24-2013 - FARA Funded Research

Therapeutic Strategies in Friedreich's ataxia
Richardson TE, Kelly HN, Yu AE, Simpkins JW
Brain Res. 2013 Apr 13. pii: S0006-8993(13)00518-0. doi: 10.1016/j.brainres.2013.04.005.
Posted: 04-24-2013

Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons
D'Oria V, Petrini S, Travaglini L, Priori C, Piermarini E, Petrillo S, Carletti B, Bertini E, Piemonte F
Int J Mol Sci. 2013 Apr 10;14(4):7853-65. doi: 10.3390/ijms14047853.
Posted: 04-24-2013

Cerebello-cerebral connectivity deficits in Friedreich ataxia
Zalesky A, Akhlaghi H, Corben LA, Bradshaw JL, Delatycki MB, Storey E, Georgiou-Karistianis N, Egan GF
Brain Struct Funct. 2013 Apr 7. [Epub ahead of print]
Posted: 04-24-2013

Mitochondrial Diseases of the Brain
Chaturvedi RK, Flint Beal M
Free Radic Biol Med. 2013 Apr 5. pii: S0891-5849(13)00123-8.
doi: 10.1016/j.freeradbiomed.2013.03.018.
Posted: 04-24-2013

Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies
Aurélien Bayot, Sacha Reichman, Sophie Lebon, Zsolt Csaba, Laetitia Aubry, Ghislaine Sterkers, Isabelle Husson, Malgorzata Rak and Pierre Rustin
Hum. Mol. Genet. (2013) doi: 10.1093/hmg/ddt144
Posted: 04-05-2013

Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia
Sirena Soriano, José V. Llorens, Laura B. Sobero, Lucía Gutiérrez, Pablo Calap-Quintana, M. Puerto Morales, M. Dolores Moltó, M. José Martínez-Sebastián
ISSN 0378-1119, 10.1016/j.gene.2013.02.049.
Posted: 04-05-2013

Assessment of upper limb function in young Friedreich ataxia patients compared to control subjects using a new three-dimensional kinematic protocol
Maurel N, Diop A, Gouelle A, Alberti C, Husson I
Clin Biomech (Bristol, Avon). 2013 Mar 25. pii: S0268-0033(13)00023-5. doi: 10.1016/j.clinbiomech.2013.02.007.
Posted: 04-01-2013

Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy
Chiranjeevi Sandi, Sahar Al-Mahdawi, and Mark A. Pook
Genet Res Int. 2013; 2013: 852080.
Posted: 04-01-2013

April 30, 2013

Race for Christina to support Friedreich's Ataxia Research

April 26, 2013

Riding through to strength
Hand cycling brings direction for Lauren Williams
as she lives with a degenerative nerve disorder

April 25, 2013

Sam Bridgman: The University of Portland student faces new challenges after college

April 11, 2013

Save The Date! Oct 14, 2013 - 6th Annual FA Symposium
Children's Hospital of Philadelphia

April 4, 2013

"Concert for a Cure" FARA benefit
Univ. of Rochester Yellowjackets sing their way into our hearts

April 4, 2013
A study at the University of Minnesota is looking for individuals who have been recently diagnosed with Friedreich’s ataxia and/or at the earlier stages and still ambulatory

May 1, 2013
Louise Aubrie - CD Release show
Manhattan, NY
Contact: John Sweeny

May 2, 2013
Putnam Valley Bible Club - Pizza Sale
Putnam Valley, NY
Contact: Carissa Burgard

Now thru May 3rd, 2013
Team Brittany - Fit for FARA Weight Loss Challenge

May 4, 2013

Team Rachel's Runners
American River Parkway Half Marathon
Sacramento, CA
Contact: FARA

May 12, 2013
5K Race for Christina
Tyler State Park
Newtown, PA
Contact: Catherine Logan

May 16, 2013
Cobb Professional Fire Fighters
9th Annual Laura Beth Golf Tournament
Marietta, GA
Contact: FARA

May 21, 2013
11th Annual DC Regional Outback Steakhouse Charity Golf Classic
Waldorf, MD
Contact: Misty Waters

May 30, 2013
Project Adventure - Team Building Day
Beverly, MA
Contact: Jean Walsh

May 31, 2013
Spark Hope Cocktail Party
Beverly, MA
Contact: Jean Walsh

The Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in Oligomerization
Christopher A. G. Soderberg, Sreekanth Rajan, Alexander V. Shkumatov, Oleksandr Gakh, Susanne Schaefer, Eva-Christina Ahlgren, Dmitri I. Svergun, Grazia Isaya, and Salam Al-Karadaghi
J. Biol. Chem. 2013; 288(12): p. 8156-8167
Posted: 03-24-2013

Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays
Lavecchia A
J Med Chem. 2013 Mar 18. [Epub ahead of print]
Posted: 03-24-2013

Bilateral cochlear implantation in Friedreich's ataxia: A case study
Frewin B, Chung M, Donnelly N
Cochlear Implants Int. 2013 Mar 9. [Epub ahead of print]
Posted: 03-17-2013

A Dynamic Model of the Proteins that Form the Initial Iron-Sulfur Cluster Biogenesis Machinery in Yeast Mitochondria
Amela I, Delicado P, Gómez A, Querol E, Cedano J
Protein J. 2013 Mar 6. [Epub ahead of print]
Posted: 03-17-2013

Friedreich's ataxia-associated GAA repeats induce replication-fork reversal and unusual molecular junctions
Follonier C, Oehler J, Herrador R, Lopes M
Nat Struct Mol Biol. 2013 Mar 3. doi: 10.1038/nsmb.2520. [Epub ahead of print]
Posted: 03-17-2013

Impact of Friedreich's Ataxia on health-care resource utilization in the United Kingdom and Germany
Giunti P, Greenfield J, Stevenson AJ, Parkinson MH, Hartmann JL, Sandtmann R, Piercy J, O Hara J, Casas LR, Smith FM
Orphanet J Rare Dis. 2013 Feb 28;8(1):38. [Epub ahead of print]
Posted: 03-17-2013

Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection
Fash DM, Khdour OM, Sahdeo SJ, Goldschmidt R, Jaruvangsanti J, Dey S, Arce PM, Collin VC, Cortopassi GA, Hecht SM
Bioorg Med Chem. 2013 Feb 13. pii: S0968-0896(13)00125-9. doi: 10.1016/j.bmc.2013.01.075. [Epub ahead of print]
Posted: 03-17-2013 - FARA Funded Research

The Reciprocal Cerebellar Circuitry in Human Hereditary Ataxia
Koeppen AH, Ramirez RL, Bjork ST, Bauer P, Feustel PJ
Cerebellum. 2013 Feb 7. [Epub ahead of print]
Posted: 03-17-2013 - FARA Funded Research

Complexes between two GAA Repeats within DNA introduced into Cos-1 cells
Krasilnikova MM
Mob Genet Elements. 2012 Nov 1;2(6):267-271.
Posted: 03-17-2013

Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by
Vitamin B3
Chan PK, Torres R, Yandim C, Law PP, Khadayate S, Mauri M, Grosan C, Chapman-Rothe N, Giunti P, Pook M, Festenstein R
Hum Mol Genet. 2013 Mar 7
Posted: 03-13-2013

A Dynamic Model of the Proteins that Form the Initial Iron-Sulfur Cluster Biogenesis Machinery in Yeast Mitochondria
Amela I, Delicado P, Gómez A, Querol E, Cedano J
Protein J. 2013 Mar 6 [Epub ahead of print]
Posted: 03-13-2013

Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia
Low SC, Corben LA, Delatycki MB, Ternes AM, Addamo PK, Georgiou-Karistianis N
J Neurol. 2013 Mar 5 [Epub ahead of print]
Posted: 03-13-2013

Very late-onset Friedreich ataxia: later than life expectancy?
Alvarez V, Arnold P, Kuntzer T
J Neurol. 2013 Feb 22 [Epub ahead of print]
Posted: 03-13-2013

Cognition in Late-Onset Friedreich Ataxia
Nieto A, Correia R, de Nóbrega E, Montón F, Barroso J
Cerebellum. 2013 Feb 9 [Epub ahead of print]
Posted: 03-13-2013

Pharmacological Screening Using an FXN-EGFP Cellular Genomic Reporter Assay for the Therapy of Friedreich Ataxia
Li L, Voullaire L, Sandi C, Pook MA, Ioannou PA, Delatycki MB, Sarsero JP
PLoS One. 2013;8(2):e55940. doi: 10.1371/journal.pone.0055940
Posted: 03-04-2013 - FARA Funded Research

March 28, 2013

Annual run spreads awareness for rare and lethal disease

March 28, 2013

Research fundraiser more than doubles goal

March 21, 2013

College student poses challenge to life-threatening disease

March 13, 2013

Josh's Journey:
The story of a young man and his constant companion

March 12, 2013

Just Like Me: The Taylor Family Foundation

March 10, 2013

Young Woman With Rare Disease Cycles through Denton

March 5, 2013
Clinical trial in Italy to test Epoetin alfa in Friedreich's Ataxia patients

April 5, 2013
YellowJackets Spring Show for FARA
University of Rochester
Rochester, NY
Contact: FARA

April 6, 2013
The FA Project
Striking Courage Bowlathon
North Reading, MA
Contact: Richie Currier

April 13, 2013
Pull for a Cure - Clay Shoot
Tampa Bay Sporting Clays
Land O Lakes, FL
Register Online  or  Register by Mail
Contact: FARA

April 16, 2013
Team FARA - SamJam 2013
Portland, OR
Contact: Sam Bridgman

April 28, 2013
Team FARA - Elizabeth Way

Flower City Half Marathon
Rochester, NY
Contact: FARA

Friedreich ataxia: neuropathology revised
Koeppen AH, Mazurkiewicz JE
J Neuropathol Exp Neurol. 2013 Feb;72(2):78-90. doi: 10.1097/NEN.0b013e31827e5762
Posted: 02-06-2013 - FARA Funded Research

Genetic Variations Creating MicroRNA Target Sites in the FXN 3′-UTR Affect Frataxin Expression in Friedreich Ataxia
Simonetta Bandiera, François Cartault, Anne-Sophie Jannot, Elie Hatem, Muriel Girard, Laila Rifai, Clemence Loiseau, Arnold Munnich, Stanislas Lyonnet, Alexandra Henrion-Caude
PLoS ONE 8(1): e54791. doi:10.1371/journal.pone.0054791
Posted: 02-06-2013

Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model
Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi-Carstens M, Carstens EE, Pook MA, Cortopassi G
Antioxid Redox Signal. 2013 Jan 27. [Epub ahead of print]
Posted: 02-06-2013

Friedreich Ataxia: Dysarthria Profile and Clinical Data
Brendel B, Ackermann H, Berg D, Lindig T, Schölderle T, Schöls L, Synofzik M, Ziegler W
Cerebellum. 2013 Jan 13. [Epub ahead of print]
Posted: 02-06-2013

Rating disease progression of Friedreich’s ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database
Günther Metz, Nicholas Coppard, Jonathon M. Cooper, Martin B. Delatycki, Alexandra Dürr, Nicholas A. Di Prospero, Paola Giunti, David R. Lynch, J. B. Schulz, Christian Rummey and Thomas Meier
Brain (2013) 136 (1): 259-268. doi: 10.1093/brain/aws309
Posted: 02-04-2013 - Partially FARA Funded

Feb 28, 2013

Rare Diseases Touch Lives

Feb 26, 2013

High school faculty raises money for student's disease

Feb 24, 2013

Pasco family deals with rare disease
as community rallies around seven-year-old

Feb 18, 2013
Press Release:
Announcing "Move YOUR Way" Initiative
for Rare Disease Day
Virtual Event to Raise Awareness
taking place February 21 - 28

Feb 12, 2013
Action Alert:
Write your Senators & Congressperson in the next 24-48 hours about NIH and FDA budget cuts

Feb 7, 2013
Altadena mother swaps wheelchair for bicycle to ride for neuromuscular disorder

Feb 7, 2013

Team FARA's Beth Bax raises awareness for FA
in the LA area

Feb 6, 2013
'Cramming 72 years into 27':
Book by late Fremont man offers inspiration

Feb 6, 2013
EPI-743 Clinical Trial begins at UCLA and CHOP
Enrollment at UCLAEnrollment at CHOP

Feb 5, 2013
FARA Spokesperson, Kyle Bryant, was honored at the Tampa Bay Lightning game on February 1, 2013 with a Team jersey by Lightning CEO Tod Lieweke in front of over 19,000 fans.
(Watch on YouTube)
Thank you Tampa Bay Lightning for raising incredible awareness of FA!

Feb 3, 2013
Altadena and Santa Clarita Women Unite In Fight to Cure Friedreich’s Ataxia

March 4 & 5, 2013
Outback Charity Nights
Multiple Locations
Contact: FARA

March 11, 2013
Outback Charity Night
Multiple Locations
Contact: FARA

March 15, 2013
Fun for FARA
Maids of Athena & Caprice Night Club
Vancouver, Canada
Contact: FARA

March 17, 2013

Team FARA - Kelly Alfieri
St. Patrick's Day 4 Miler
Powell, OH
Contact: FARA

March 18 & 19, 2013
Outback Charity Nights
Multiple Locations
Contact: FARA

March 21, 2013
Donkey Basketball
Penn Laird, VA
Contact: Natalie McCrady

March 22, 2013
Lone Star Benefit Bash
Flower Mound, TX
Contact: Performance Award Center

March 23, 2013
Ride Ataxia - rideDALLAS
Denton, TX
Contact: FARA

March 23, 2013
A Night of Mystery
Masquerade Ball to Cure Friedreich's Ataxia
Mineral Wells, WV
Contact: Melissa Gordon

March 30, 2013
Rabbit Run
Bakersfield, CA
Contact: Carrie Laird