Drug Discovery/Improving Clinical Outcomes:
Title: Endurance and resistance exercise mitigate Friedreich’s ataxia
PI: Zhen Yan, University of Virginia
*Funded in part by the Phillip Bennett Memorial Fund
This research grant builds on prior funded work evaluating the impact of exercise in an FA mouse model. The overall objectives of this proposal are to determine if resistance exercise and endurance exercise are equally effective in preventing symptoms of FRDA in mice and to elucidate how endurance exercises exert the positive impact. The proposed studies will provide new insights into interventions to the etiology of FRDA and pave the way for the development of innovative exercise-based interventions for management and therapy.