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Src inhibitors modulate frataxin protein levels

Defective expression of frataxin is responsible for the inherited, progressive degenerative disease Friedreich's Ataxia (FRDA). There is currently no effective approved treatment for FRDA and patients die prematurely. Defective frataxin expression causes critical metabolic changes, including redox imbalance and ATP deficiency. As these alterations are known to regulate the tyrosine kinase Src, we investigated whether Src might in turn affect frataxin expression. We found that frataxin can be phosphorylated by Src.

 

Read More: Src inhibitors modulate frataxin protein levels.

 


About the Author

Jen Farmer

Jen Farmer

Executive Director

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