Accept Cookies?
Provided by OpenGlobal E-commerce

Please wait while your page loads ...

FARAFARA Cure FA

Friedreich's Ataxia (GAA)(n)-(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae

Expansions of trinucleotide GAA-TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA-TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)-(TTC)(230) stimulate mitotic crossovers in yeast about 10,000-fold relative to a "normal" DNA sequence; (GAA)(n)-(TTC)(n) tracts, however, do not significantly elevate meiotic recombination. Most of the mitotic crossovers are associated with a region of non-reciprocal transfer of information (gene conversion). 

Friedreich's Ataxia (GAA)(n)-(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae


About the Author

Jen Farmer

Jen Farmer

Executive Director

SHARE

FacebookTwitterLinkedinShare on Google+
Event C.jpg

 

Archived in
  Scientific News


 

 

Tagged in
FARA Scientific News