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Heterotrifunctional chemical crosslinking mass spectrometry confirms physical interaction between human frataxin and ISU

The progressive neurodegenerative disease Friedreich's ataxia is caused by a decreased level of expression of frataxin, a putative iron chaperone. Frataxin is thought to transiently interact with ISU, the scaffold protein onto which iron-sulfur clusters are assembled, to deliver ferrous iron.

Read More: Heterotrifunctional chemical crosslinking mass spectrometry confirms physical interaction between human frataxin and ISU

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