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FARAFARA Cure FA

Iron-dependent functions of mitochondria-relation to neurodegeneration

A number of neurodegenerative diseases are associated with iron dyshomeostasis and mitochondrial dysfunction. However, the pathomechanistic interplay between iron and mitochondria varies. This review summarises the physiological role of iron in mitochondria and subsequently exemplifies two neurodegenerative diseases with disturbed iron function in mitochondria: inherited Friedreich ataxia (FRDA) and idiopathic Parkinson disease (PD). In eukaryotes, mitochondria are main consumers of iron.

Iron-dependent functions of mitochondria-relation to neurodegeneration


About the Author

Jen Farmer

Jen Farmer

Executive Director

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