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FARAFARA Cure FA

Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia

Friedreich ataxia (FA) is a neurodegenerative and cardiodegenerative disease resulting from marked frataxin deficiency. The condition is characterized by ataxia with fatal cardiomyopathy, but the pathogenic mechanisms are unclear. We investigated the association between gene expression and progressive histopathological and functional changes using the muscle creatine kinase conditional frataxin knockout (KO) mouse; this mouse develops a severe cardiac phenotype that resembles that of FA patients.

Read More: Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia


About the Author

Jen Farmer

Jen Farmer

Executive Director

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