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Structure-function analysis of Friedreich's ataxia mutants reveals determinants for frataxin binding and activation of the Fe-S assembly complex

Friedreich's ataxia (FRDA) is a progressive neurodegenerative disease associated with the loss of function of the protein frataxin (FXN) that results from low FXN levels due to a GAA triplet repeat expansion or, occasionally, from missense mutations in the FXN gene. Here biochemical and structural properties of FXN variants, including three FRDA missense mutations (N146K, Q148R, and R165C) and three related mutants (N146A, Q148G, and Q153A), were determined in an effort to understand the structural basis for the loss of function. 

Structure-function analysis of Friedreich's ataxia mutants reveals determinants for frataxin binding and activation of the Fe-S assembly complex


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Jen Farmer

Jen Farmer

Executive Director

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