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FARAFARA Cure FA

The role of frataxin in fission yeast iron metabolism: Implications for Friedreich's ataxia

BACKGROUND:

The neurodegenerative disease Friedreich's ataxia is the result of frataxin deficiency. Frataxin is a mitochondrial protein involved in iron-sulfur cluster (Fe-S) cofactor biogenesis, but its functional role in this pathway is debated. This is due to the interconnectivity of iron metabolic and oxidative stress response pathways that make distinguishing primary effects of frataxin deficiency challenging. Since Fe-S cluster assembly is conserved, frataxin overexpression phenotypes in a simple eukaryotic organism will provide additional insight into frataxin function.

Read More: The role of frataxin in fission yeast iron metabolism: Implications for Friedreich's ataxia


About the Author

Jen Farmer

Jen Farmer

Executive Director

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