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FARAFARA Cure FA

Turning Yeast into a Frataxin-Independent Organism

Frataxin (Yfh1 in yeast) is a conserved protein and deficiency leads to the neurodegenerative disease Friedreich's ataxia. Frataxin is a critical protein for Fe-S cluster assembly in mitochondria, interacting with other components of the Fe-S cluster machinery, including cysteine desulfurase Nfs1, Isd11 and the Isu1 scaffold protein. Yeast Isu1 with the methionine to isoleucine substitution (M141I), in which the E. coli amino acid is inserted at this position, corrected most of the phenotypes that result from lack of Yfh1 in yeast.

 

Read More: Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism


About the Author

Jen Farmer

Jen Farmer

Executive Director

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