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Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

Folding and function may impose different requirements on the amino acid sequences of proteins, thus potentially giving rise to conflict. Such a conflict, or frustration, can result in the formation of partially misfolded intermediates that can compromise folding and promote aggregation.

Read More: Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein


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Jen Farmer

Jen Farmer

Executive Director

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