Pharmacol Res. 2015 Jul 2. pii: S1043-6618(15)00113-9. doi: 10.1016/j.phrs.2015.05.015. [Epub ahead of print] Abeti R, Uzun E, Renganathan I, Honda T, Pook MA, Giunti P

Fibroblasts from two FRDA mouse models, YG8R and KIKO, were used to analyse two different categories of protective compounds: deuterised poly-unsaturated fatty acids (dPUFAs) and Nrf2-inducers. The former have been shown to protect the cell from damage induced by lipid peroxidation and the latter trigger the well-known Nrf2 antioxidant pathway. Our results show that the sensitivity to oxidative stress of YG8R and KIKO mouse fibroblasts, resulting in cell death and lipid peroxidation, can be prevented by d4-PUFA and Nrf2-inducers (SFN and TBE-31).

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