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Mitochondrial capacity, muscle endurance & low energy in friedreich ataxia

The group evaluated skeletal muscle mitochondrial capacity, muscle-specific endurance, and energy/fatigue feelings in sixteen people with Friedrich ataxia and compared them to ten controls. Forearm mitochondrial capacity was measured using the rate of recovery of oxygen consumption after electrical stimulation with near-infrared spectroscopy. Mechanomyography (MMG) assessed muscle endurance after electrical stimulation for 3-minutes at 2Hz, 4Hz, and 6Hz. Validated scales assessed disease severity and energy/fatigue feelings. Groups did not differ in mitochondrial capacity.

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