Expanded trinucleotide repeat sequences are the cause of several inherited neurodegenerative diseases. Disease pathogenesis is correlated with several features of somatic instability of these sequences, including further large expansions in postmitotic tissues. The presence of somatic expansions in postmitotic tissues is consistent with DNA repair being a major determinant of somatic instability.
Read More: Pms2 Suppresses Large Expansions of the (GAA·TTC)(n) Sequence in Neuronal Tissues
