Accept Cookies?
Provided by OpenGlobal E-commerce

Please wait while your page loads ...

Sudomotor dysfunction is frequent and correlates with disability in Friedreich ataxia

This study set out to evaluate autonomic symptoms and function in Friedreich's Ataxia (FRDA).Twenty-eight FRDA patients and 24 controls underwent clinical/electrophysiological testing. They used the Friedreich's Ataxia Rating Scale (FARS) and the Scales for Outcomes in Parkinson's Disease: Autonomic Questionnaire-SCOPA-AUT to estimate the intensity of ataxia and autonomic complaints, respectively. Cardiovagal tests and the quantitative sudomotor axonal reflex, Q-SART, were then assessed in both groups. In the patient group, there were 11 men with mean age of 31.5 ± 11.1 years. Mean SCOPA-AUT score was 15.1 ± 8.1. Minimum RR interval at rest was shorter in the FRDA group (Median 831.3 × 724.0 ms, p < 0.001). The 30:15 ratio, Valsalva index, E:I ratio, low and high frequency power presented no differences between patients and controls (p > 0.05). Sweat responses were significantly reduced in patients for all sites tested (forearm 0.389 × 1.309 µL; proximal leg 0.406 × 1.107 µL; distal leg 0.491 × 1.232 µL; foot 0.265 × 0.708 µL; p value < 0.05). Sweat volumes correlated with FARS scores. Overall, they found abnormal sudomotor but normal heart rate variability in FRDA. Small cholinergic post-ganglionic fibers were affected in the disease. They conclude that quantification of sudomotor function might be a biomarker for FRDA.

Read the entire article HERE


Scientific News Archives

Tagged in
Scientific News


Privacy Policy      Service Terms      Contact      Charity Navigator