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Teen Hangouts: Presented by the FARA Ambassador Program
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Activities & Events Blog
rideATAXIA Philly 2018
Slim's Journey 2018
Friedreich's for Nobode
"The Ataxian" Screening
16th Annual Fuzzy Buzzy Golf Tournament
Beads for Hope Fundraiser
FA Woodstock 2018
Jumpin' for Jazz Fundraiser Hit the High Notes
6th Annual Mother’s Day Race for Christina
A Night to Fight FA Round 2
More Than Pizza
Cure FA Soirée: React with Music
2018 FArm to Table
8th Annual Pull for a Cure
UCLA/FARA Friedreich's Ataxia Patient Symposium
3rd Annual Costume for a Cure
A Weekend to Remember
The 8th Annual Race for Matt & Grace
Union Jack's British Pub Party
The Ataxian Screening - Lee's Summit, MO
10th Annual McDonnell Music Festival
Slim's Journey
Pizza, Golf and an Award Winning Documentary
2017 FA Adventure Day
2017 Global Genes RARE Patient Advocacy Summit
Quartermania for FARA
FA Indy Family 5k Run/Walk
Kern County's Annual Reverse Draw for FARA
Inaugural Race for Matt & Grace Golf Tournament
Louisiana Screenings of 'The Ataxian'
Friedreich's Ataxia Awareness Day 2017
A Night to Fight FA
2017 FArm to Table
9th Annual Anytime Fitness Charity Golf Scramble
2017 FARA/University of Iowa FA Patient Symposium
FA Patient Focused Drug Development Meeting - Your opportunity to tell the FDA what is important to you in finding a treatment for Friedreich’s Ataxia
2017 Move Your Way for Rare Disease Day
Pictures of HOPE
Knock Out FA
"Ghouls Night Out"
2016 Century 21 Charity Golf Tournament
5th Annual Slim's Journey
FA Adventure Day 2016
Whitewater Rafting with SPLORE
Oktoberfest Party for FARA
2016 FARA Energy Ball
2016 Fuzzy Buzzy Golf Tournament
FA Indy Family Fun Walk/Run
2016 Claxton Classic Golf Tournament
FA Woodstock 2016
16th Annual Claxton Classic Wing Party
Curtain Call for a Cure
Funny 4 Funds 2016
New Jersey Seaside Stride 2016
The Ataxian in Athens
Emory University FA Patient Symposium 2016
FARA FEST 2016
4th Annual Mother's Day 5K Race for Christina
2016 FA Awareness Day Video Clip Campaign
A Marathon, a Pint and a Slice for FARA
"Brunch and Learn" at Reata Pharma
Pull for a Cure 2016
McAlister's and Freddy's Give Back
Roundtable for Rare Disease
UCLA/FARA Symposium
Rock Around the Clock for FARA
2015 Ace for a Cure
FArm to Table Dinner
Costume for a Cure!
6th Annual Swing Away at FA
CHOP Symposium 2015
6th Annual Race for Matt & Grace
F.A.T. Run
8th Annual McDonnell Music Festival
2015 USF Health Scientific Symposium and FARA Energy Ball
12th Annual Fuzzy Buzzy Golf Tournament
4th Annual Slim's Journey Run and Walk
Funny 4 Funds Comedy Night
2015 FA Adventure Day
9th Annual Welsh Bash in the Backyard
Claxton Classic and Wing Party
Summer FUNdraising in RI
2015 Seaside Stride Luncheon
6th Annual Race for Matt and Grace Kick-off
25th Annual Doubles Charity Tennis Tournament
3rd Annual 5k Mother's Day Race for Christina
Flatbread Benefit Night 2015
Iowa City FA Conference
6th Annual Striking Courage Bowlathon
Concert for Christina
FARA FEST 2015
Anytime Fitness Golf Tournament
Ride Ataxia Dallas 2015
Masquerade Where Wishes Come True
Cure Us Portland
Rare Disease Day 2015
#AnnasArmy Purple Out
Team FARA: Team Mustangs for Alison
Ride Ataxia Orlando 2014
Ride Ataxia Philadelphia and CHOP Medical Symposium 2014
5th Annual Swing Away at FA
Voyager Therapeutics Ribbon Cutting Ceremony
Rocky Mountain Bird & Birdie
Slim's Journey of Hope
Hole Out for a Cure
5th Annual Race for Matt and Grace
Friends of Jerod Reverse Draw
Pfizer and FARA: Rare Disease Community Outreach
USF Scientific Symposium and FARA Energy Ball 2014
11th Annual Fuzzy Buzzy Golf Tournament
Welsh Bash in the Backyard
Ride Ataxia Seattle
FA Woodstock and Ride Ataxia Chicago 2014
FA Adventure Days 2014
Flatbread Pizza: Race for Matt and Grace
Ride Ataxia Orlando
Swing Away at FA
Ride Ataxia Portland
6th Annual Century 21 King Golf Classic
Fuzzy Buzzy 2013
FA Woodstock and Ride Ataxia Chicago
Flatbread & Fisherman's Fundraiser
Springfield Outback Fundraiser
Adventure Day
FA Hangouts - February 2021
FARA Teen Hangouts - February 2021
FARA Teen Hangouts - January 2021
FA Hangouts - January 2021
September FA Teen Hangout 2019
September FA Hangout 2019
FA Adventure Day 2019
July FA Hangout 2019
FAmily Friend Set to Climb Mt. Kilimanjaro and Raise Money for FA
FA Awareness Day Luau 2019
7th Annual Mother's Day 5K Race for Christina
Cure FA Soirée: React with Music 2019
Teen Hangout - May 2019
May FA Hangout 2019
Patient Perspective: Brittany's Experience Participating in Research Studies
Advocacy - Our Voices Roar When Joined with Others
Family Weekend in Philly
Patient Perspective: Jean Walsh's Decision to Participate in TAK-831
Young Adult Representatives of RDLA Event
Lenny and Joe's Carousel
Patient Perspective: Antonio's Experience Participating in a Clinical Trial
Brittany Sommerfield - My Solo Wheelchair Journey
Rare Disease Week 2018
Patient Perspective: Christina's Experience Participating in a Clinical Trial
Patient Perspective: Kyle's Experience Participating in a Clinical Study
Patient Perspective: Stephanie's Experience Participating in a Research Study
Patient Perspective: Shandra's Experience Participating in a Clinical Study
Celebrating the Joy of Happiness
Remembering Paige Myers, FARA Ambassador
Ambassador Program Applications 2017
Patient Perspective: Leah's Experience Participating in a Research Study
Visiting FARA Funded Researchers
Patient Perspective: Frankie's Experience Participating in a Clinical Trial
Patient Perspective: Michael's Experience Participating in a Clinical Trial
A Mom's Perspective on Participating in Clinical Research
Patient Perspective: Jake's Experience Participating in Clinical Research Studies
Bracelets to #cureFA!
ADVOCACY ALERT: United Rare Disease Day of Action for #CuresNOW
A Time to Connect, Share, Learn and HOPE
Research Labs and Hope in North Carolina
Bringing It Home
Patient Perspective: Sean's Experience Participating in a Clinical Research Study
Drug Access and Supplements
Ambassador Program Applications 2016
Patient Perspective: Alex's Experience Participating in a Clinical Research Study
Patient Perspective: Jamie & Jean's Experience Participating in the Natural History Study
Drug Approvals and What Happens Next
Patient Perspective: Kyle's Reflection on the Importance of Being an Active Participant in Research
Patient Perspective: Mandy's Experience Participating in a Research Study
Patient Perspective: Tricia's Experience Participating in a Research Study
Patient Perspective: Liam's Experience Participating in a Research Study
Patient Perspective: Mary's Experience Participating in a Research Study
Patient Perspective: Abby & Chase's Experience in a Research Study
Accelerating Drug Development and Clinical Trials
The Drug Development Pathway
Ambassador Review: Pipeline Progress and Clinical Trials
How to Breathe at 12,000 Feet
The Big Study in the Big Apple
A Whole Lotta Love for FA Hangouts
Research Spotlight: Bidichandani Lab
Sean Mazeres
Kendall Harvey
Joseph Mullaney
Wenses Reyes
Abby Y
A Look Behind the Scenes
Spotlight on Iain Fryatt
Remembering FARA Director Nick Johnson
Spotlight on Natache Iamaya
Research Spotlight: Dr. Marek Napierala
Pull for a Cure
FARA Family Fun Day Fundraiser on the Farm
MTC Gratitude
Happy New Year 2015!
FARA Newsletter
The FARA Ambassador Program presents FA Hangouts
Ap Gravatar
Spotlight on Gunnhild (Andreassen) Lystad
Jack's Weapons of Grass Destruction Tour
Spotlight on Patrick Cogan
Spotlight on Emily
Ambassador Program Commitment Description
Spotlight on Kiela Acker-Williams
Lonestar Benefit Bash Golf Tournement
Beth Bax
Spotlight on Barry Rice, Founder of Cycle Ataxia
Sean Baumstark
Megan
HOPE
The FARA Ambassador Program
Ambassador Program Projects
Ambassadors LT
Jeannie Kinney
Christina Logan
RA Philly & CHOP Symposium
Catherine Brent
Diversity Among Wheelchair Users
We Care About Rare
Emily Penn
2013 FARA Energy Ball
Lauren Williams
Michelle Huebner
30 Years and still Fighting
Mary Vida
A Milestone Ride
The Face of Strength
Arts & Creativity
Opportunities for Understanding
Research funding is a precious resource
Methodically Falling Prey
Richie Currier
The Blackburn Challenge
Telling Friends and Family about FA
World of Beer Fundraiser
John
The Maryland Youth Leadership Forum
Collaboration for a Cure!
Eric
Regina
FARA Ambassadors
Our Partners
Advocacy
Media
News & Press Releases
FARA Advocacy Newsletter - Feb 2021
Rare Disease Day is February 28th, 2021!
NAF and FARA welcome the 117th Congress
A Community Statement from Novartis Gene Therapies
Monthly Update - February 2021
Information on COVID-19 and Friedreich's Ataxia
Monthly Update - January 2021
Webinar: FA Community Call to Action on January 5, 2021
Friedreich's Ataxia Center of Excellence at CHOP Awarded $1.275 Million to Advance Medical Research
Monthly Update - December 2020
Central Nervous System Therapeutic Targets in Friedreich Ataxia
December 1st is Giving Tuesday!
PTC Therapeutics Announces Initiation of Global Phase 3 Clinical Trial to Evaluate Vatiquinone in Friedreich Ataxia
U.S. Senate passes the Bipartisan "NATIONAL ATAXIA AWARENESS DAY OF 2020" resolution
The inaugural International Congress for Ataxia Research (ICAR)
Monthly Update - November 2020
Monthly Update - October 2020
New ICD-10-CM Diagnosis Code G11.11 for Friedreich’s Ataxia Effective October 1, 2020
Global, multi-stakeholder, consortium launched to study neuroimaging biomarkers for Friedreich Ataxia
rideATAXIA Global Challenge
Award for Innovative Mindset
Monthly Update - August 2020
FARA Job Posting - Communications Coordinator
Third Party Data Breach
Monthly Update - July 2020
NAF and FARA will be holding their second Hill day on September 10, 2020
Strong Partnership Funds the 2020 Ataxian Athlete Initiative (AAI) for People with Ataxia
PTC Therapeutics will be hosting an Informational Patient Webinar on July 28th
Monthly Update - June 2020
FA Research Update
Monthly Update - May 2020
FARA hires Barbara Tate, PhD as FARA’s New Chief Scientific Officer
Help FARA Earn a $20,000 Matching Gift- Now Through the End of May!
FARA is excited to launch our FA Research Flash Talk series
Monthly Update - April 2020
Why the FA Global Patient Registry is Important to Me
rideATAXIA Dallas 2020 - Thank you!
A Note to Our Community Regarding COVID-19
FARA job posting - rideATAXIA Event Coordinator
The Friedreich’s Ataxia Research Alliance Promotes Jennifer Farmer, MS to Chief Executive Officer
2019 International Ataxia Research Conference is a Success!
Freidreich's Ataxia: The CHUM and its partners involved in an international study to better understand the disease and its progression over time
Global Ataxia Advocacy Organizations Unite to Host International Ataxia Research Conference in Washington, DC
Reata Announces Positive Topline Results from the MOXIe Registrational Trial of Omaveloxolone in Patients with Friedreich’s Ataxia
12th Annual Friedreich's Ataxia Symposium at CHOP
Kyle Bryant Living Life Beyond Circumstances
Bike ride along I&M Canal in Channahon raises funds for rare disease research
From patient to Researcher
Advocacy 101: Jump In
Joe Brown, 28, inspired his Carolina classmates, loved the Tar Heels and never gave up
Becoming Involved in the FA Community Was the Best Decision I’ve Made
7th grader with neuromuscular disorder scores first touch down with help from teammates
River Ridge Middle School player scores touchdown
'It's just frustrating': Evansville teen Sam Archuleta battling debilitating disease
The 9th Annual FARA 5K is just around the corner
US Open stars embrace chance to give back through charity work
Race for Matt and Grace golf tournament gets assist from Johnston Firefighters
11th Annual Friedreich’s Ataxia Symposium - Registration Open!
FARA and the Burrows Hill Foundation Announce the Recipients of the 2018 Ataxian Athlete Initiative (AAI)
Invite and They Just Might Come!
FARA job posting - Research Portfolio Manager
For Father's Day, this dad just wants a cure for his daughter
North Branford siblings speak-out about growing-up with devastating disabilities
Football team makes classmate's wish come true
Howell High School's Senior Survivor Raises Record-Breaking Amount
Lend Us Some Muscle! 2018
Life Is About How We React - Rare Disease Day - February 28th
THE ATAXIAN Kicks Off Rare Disease Week on Capitol Hill
You May Be Going to the Super Bowl!
FARA Job Posting: Communications Coordinator
Tell Congress to Keep the Orphan Drug Tax Credit!
Friedreich’s Ataxia Community Stays on Top of Science and Stays in Touch
FARA Announces Recipients of the 2017 Ataxian Athlete Initiative (AAI)
Girl tells author of ‘Wonder’ how book hit close and closer to home
Friedreich’s Ataxia “Voice of the Patient” report
10th Annual Friedreich’s Ataxia Symposium at CHOP
Fitchburg lawyer battling rare disease: ‘I want to walk’
Student battling rare disorder — with a smile — wins national writing contest
Four National Organizations, Hundreds of Families Impacted, Join Together to Speak with FDA about Drug Development in Friedreich’s Ataxia
FARA to Ring The Nasdaq Stock Market Closing Bell - Friday, May 19th
JOIN AN UPCOMING LIVE WEBINAR TO LEARN ABOUT THE PATIENT FOCUSED DRUG DEVELOPMENT MEETING
Rare Disease Week on Capital Hill, February 27 - March 2, 2017
FA Patient Focused Drug Development Meeting - Your opportunity to tell the FDA what is important to you in finding a treatment for Friedreich’s Ataxia
Get Involved: Friedreich’s Ataxia Patient Focused Drug Development (PFDD) Meeting
2nd International Ataxia Research Conference - September 27-30, 2017 - Pisa, Italy
Family, neighbors unite to fight genetic disorder
The latest Advocate Newsletter is available
FARA Job Posting: Patient Engagement Director
New York Times Review: A Race to Raise Awareness in ‘The Ataxian’
FARA Joins Nasdaq’s Live Broadcast on #GivingTuesday
9th annual FA Symposium - Oct 17th, 2016
These families who share a rare disease just gathered for an international reunion. It may speed along a cure.
The Caregiver’s Challenge: Making Clinical Decisions for Your Child
Save The Date - 9th annual FA Symposium - Oct 17th, 2016
High School students raise money for Friedreich's Ataxia
What it’s like to be a teenager whose body is ground zero for a life-saving medical discovery
Cycle to raise awareness of incurable condition
Ataxia Research Center at USF is looking for volunteers
Ashley Sturm - "My last story here at WTAP may be the most important I've ever told."
"I couldn’t just sit and wait for a cure": How this man is raising funds to research his rare condition
Park High School graduate profile: Diagnosis altered Mekayla Holm's plans
St. Catherine’s Academy raises money to fight Friedreich’s Ataxia, heart disease
FARA receives 2016 NORD Rare Impact Award
DOING AS MUCH AS A MOM CAN
TRAIN - Innovator Spotlight on the Friedreich's Ataxia Research Alliance
Arizona woman to swim across state lakes for rare disease research
Make it a FARA Weekend in Philly!
Tod Leiweke Honored as Lightning Community Hero
Anna's Army Movie Star Masquerade Ball was held Saturday night
NORD Announces 2016 Rare Impact Award Recipients to be Honored on May 17
BWW Review: THE ATAXIAN, Powerful and Inspiring : The Life Well Lived Is The Life Well Raced
The Ataxian movie shows at the Sedona Film Festival
Saratoga County families highlighted in Rare Disease Movie Night
2015 FARA grassroots events raise over $1 Million for FA research!
Former teacher continues to beat the odds
Gavin Lambert, 10, doesn't allow disorder to hold him back
Ron Bartek receives Lifetime Achievement Award
Testing the FA-ITH Four Years Later
UAB Researchers Receive Funding to Seek Biomarkers in Friedreich's Ataxia
Fourth-grader's family, friends take up fight against her genetic disorder
Emotional Homecoming Crowning Brings Awareness
NORD Issues Statement Applauding the Approval of Ensuring Access to Clinical Trials Act
Sigma Phi Epsilon Raising Awareness and Research Dollars
USF Health and FARA to host Sept. 17 scientific symposium
MDA and FARA Partner to Advance Treatments and Care for Friedreich's Ataxia
Retrotope announces open enrollment for Friedreich's ataxia clinical trial
Set for 6th year, Race for Matt and Grace continues to grow
REGISTRATION OPEN!- Children's Hospital of Philadelphia Eighth Annual Friedreich's ataxia Symposium
US House of Representatives Pass 21st Century Cures
FARA receives 4 star Charity Navigator rating for 5th year in a row
Horizon Pharma plc Initiates Phase 3 Trial of ACTIMMUNE(R) (interferon gamma-1b) for the Treatment of People With Friedreich's Ataxia
Two sites open and subjects, ages 10-25 years, needed for Phase III study of ACTIMMUNE in Friedreich's ataxia
World Premiere of “The Ataxian”: Documentary Features Biking Icon Kyle Bryant’s Legendary Ride Across America
Rep. Gerry Connolly of VA recognizes FA Awareness Day in the House of Representatives
Retrotope's dPUFA therapeutic approach in FA highlighted in New Scientist article
Race for Christina 5K Race Set for Mother's Day at Tyler State Park
Horizon Pharma plc Receives FDA Fast Track Designation for ACTIMMUNE(R) in the Treatment of Friedreich's Ataxia
RTA 408 Phase 2 Trial now enrolling at Emory University
Catrike Ends Rally to Focus on FARA
MassBio News Patient Profile: Jean Walsh
University of Portland graduate Sam Bridgman to speak at fundraiser for rare disease
International Ataxia Research Conference 2015
State Government, Pharmaceutical Industry, and Patient Community partner together
Horizon Pharma plc Submits Investigational New Drug Application for ACTIMMUNE(R) in the Treatment of Friedreich's Ataxia
Voyager Therapeutics & Genzyme Announce Major Strategic Collaboration
Dr. Randy Feldman of Feldman Orthodontics Honored as a Tampa Bay Lightning Community Hero
Move Your Way for Rare Disease Day 2015
Developing a new tool to measure how nerves are affected in FA
Reata Enrolls First Patient in the MOXIe Study, a Phase 2/3 Study Examining RTA 408 in Friedreich's Ataxia Patients
Phase 2 Trial with RTA 408 now enrolling at University of Florida
Choosing Happiness
Horizon Pharma announces plans for Phase 3 trial of Acctimmune in Friedreich's ataxia
7th Annual CHOP FA Symposium Video Now Available
FARA Funds Four New Research Grants
The Advocate - Winter 2014-2015
Consensus Clinical Management Guidelines for Friedreich Ataxia
Study of Cardiomyopathy in FA Patients
Restaurateur Hosts NB 'Hearts of Hope' Benefit Shopping Night
Phase 2 Trial with RTA 408 now enrolling at CHOP Recruitment Notice:
'Nutcracker Tea' to fight a rare disease
Kyle Bryant is Gearing Up for Ride Ataxia 2014
Family making a difference in Friedrich's Ataxia Research
Reata Announces the Initiation of Phase 2 Studies Examining RTA 408 for the Treatment of Friedreich's Ataxia and Mitochondrial Myopathies
"Tremendous progress" in race against Friedreich's ataxia highlighted at USF-FARA scientific symposium
Albert Richard awarded 'Young Champion'
"We're not alone anymore": 5th Race for Matt and Grace to support fight against Friedreich's ataxia
Chondrial Therapeutics, LLC launched to advance protein replacement for FA Business story:
A Tampa Bay Rays Gameday Experience with Gavin Lambert
Kyle Bryant receives first-ever AANEM Public Recognition Award
Your invitation to the 7th Annual CHOP FA Symposium on Oct 13th, 2014
Ride Ataxia; to raise awareness of debilitating disease
2014 Ride Ataxia helping to make a difference
International effort to fill gap in Friedreich's ataxia research
The Advocate - Summer 2014
Attn Young Investigators - Call for Abstracts 7th Annual Friedreich's Ataxia Symposium
Abstract Submission Form
REGENX has granted Voyager a non-exclusive worldwide license
Ride raises money for rare disease research
Alameda: Family riding to save lives, raise awareness of rare disease
Join Us in the "We Believe" Initiative for FA Awareness Day
REGENX Biosciences Enters Into License Agreement With AAVLife for Development of Treatments for Friedreich's Ataxia Using NAV(R) Vectors
"Portraits of Courage" to Honor Spirit of Patients and Families at Annual NORD Gala
AAVLife start-up company to advance cardiac gene therapy in FA announces Series A funding
International collaboration advances gene therapy for Friedreich's ataxia
Anna Gordon raises awareness for the upcoming Masquerade Ball to benefit FARA
FDA Grants Fast Track Status to Edison Pharmaceuticals' EPI-743 for Friedreich's Ataxia
Edison Pharma Press Release
Woman Battles Genetic Condition on the Road
Determination and focus help two cousins achieve their dreams
$3.25 Million Gift Creates Penn Medicine/CHOP Friedreich's Ataxia Center of Excellence Media Coverage
Gavin Lambert meets John Isner at Ace for a Cure
Voyager Therapeutics, a new gene therapy company focused on CNS diseases, is launched.
Second Annual Move YOUR Way for Rare Disease Day
Local College Student Battling Rare Disease Goes from Sidelines to Cyclist
FDA Grants Edison Pharmaceuticals' EPI-743 Orphan Status for Friedreich's Ataxia
Edison Pharmaceuticals, Inc. announces a strategic alliance with Dainippon Sumitomo Pharma Co., Ltd.
Sixth-Grader Grace Haupt Navigates Life with Spirit and Drive
International patient advocates partner to fund Spanish gene-therapy project to treat Friedreich's ataxia
FARA has 2 Tickets to the Super Bowl for Auction
Repligen Corporation Announced BioMarin Pharmaceutical Acquired Assets in HDAC Inhibitor Program
Safety and Pharmacology Study of VP 20629 in Adults With FA
Amanda - Meeting Justin Timberlake
Predictive Testing in FA Survey - Invitation for FA patients and their immediate family members
Sixth Annual Friedreich's Ataxia Symposium at CHOP Recorded October 14, 2013
The Tampa Bay Lightning honors Paul and Suzanne Avery as Lightning Community Heroes of the year
Agilis Biotherapeutics Completes $8 Million Financing to Develop DNA based Therapeutics
The Advocate Winter 2013 - 2014
Friedreich’s Ataxia Research Alliance honors Clear Channel Outdoor as Media Partner of the Year
Friedreich’s Ataxia Research Alliance recognizes the Tampa Bay Lightning as Partner of the Year
Ace For A Cure with John Isner raising funds for FA research
North Branford shopping event Dec 7th to fight rare disease
Coming Together for a Cure - 8th Annual Stephanie's Hope Holiday Boutique
FARA earns the highest rating (4 Stars) from Charity Navigator for the 4th consecutive year!
USF is currently recruiting FA patients for a study of EPI-743 in Friedreich's Ataxia Point Mutations
N. Ga. family opens up about efforts to battle rare disease
6th Grader's Outlook On Life Inspires Those Around Her
Athelete's Diagnosis Inspires Multi-Million Dollar Fundraising Ride
Pioneering Research of a Rare Neurological Disorder
Dr. Robert Dean and The Lambert Family talk about Living with Friedreich's ataxia
Celebrating Ataxia Awareness Day, we announce the Keith Michael Andrus Cardiac Research Grant
'If I can affect change in other people’s live ... that can be really powerful'
Dozens ride to raise awareness about rare neuro-muscular disease
Sam Bridgman pedaling for a cure in Ride Ataxia Portland
Mapping the anatomical and functional connectivity of the Central Nervous System in Friedreich’s Ataxia using Magnetic Resonance Imaging
FARA Energy Ball 2013 Video
Tampa at center of research to cure rare disease
Clinical Research at USF may develop treatment for difficult neuromuscular disease
Recruitment Notice: Study of interferon gamma-1b (Actimmune™) for the treatment of FA at CHOP
Announcing the 6th Annual Friedreich's Ataxia Symposium at CHOP
Announcing the FARA/USF Health Science Symposium
FARA recently met with Senator Bob Casey to give the patient perspective on NIH budget sequestration
Clinical Trial Announcment: Call for Patients with FA Phase I Trial with VP-20629 at CHOP
Prominent Friedreich’s ataxia spokesperson and advocate to participate in University of Minnesota study
New Newsletter Available: The Advocate Summer 2013
Villa Park teen rides to raise money for her rare disorder
Have Wheels, Will Ride: Teenage Girl Pedals After Medical Breakthrough
Interview with Kristin Jones Winner of 10 mile Swim in Vermont for Team Ryan and Owen Jones
Emily Young and Ride Ataxia on ABC 7 Chicago
GCMS senior to ride for cure in Channahon
Cody Brunette tops Swim Around Key West
FARA Webinar – FA Treatment Pipeline Update Tuesday June 18th 12:00pm EST
Va. Beach event targets neuro-muscular disorder
Kyle Bryant From Ride Ataxia
Poem by Christian Maugee: A Disease Unlike the Rest
Friedreich's Ataxia Awareness Day is Saturday, May 18th 2013
Swimming for a cause, swimming for family
Sam Bridgman Stands From Wheelchair, Walks Across Stage At College Graduation
Join Us in "A New FA" Initiative for FA Awareness Day
Fundraising for Friedreich’s Ataxia: Concert for a Cure was a Huge Success
Rochester Undergrads Raise $20K for Rare Disease Research
Race for Christina Will Support Friedreich's Ataxia Research
Glen Burnie woman rides through adversity to strength
Sam Bridgman: The University of Portland student faces new challenges after college
Save The Date! Oct 14, 2013 - 6th Annual FA Symposium
Students lead awareness campaign for rare genetic disease, YellowJackets contribute
A study at the University of Minnesota is looking for individuals who have been recently diagnosed with Friedreich’s ataxia
Annual run spreads awareness for rare and lethal disease
Just Like Me: The Taylor Family Foundation
Young Woman With Rare Disease Cycles through Denton
Rider Not Letting Ataxia Stop Race For Awareness
Rare Diseases Touch Lives
Pasco family deals with rare disease as community rallies around seven-year-old
Announcing "Move YOUR Way" Initiative for Rare Disease Day
Altadena mother swaps wheelchair for bicycle to ride for neuromuscular disorder
Team FARA's Beth Bax raises awareness for FA in the LA area
'Cramming 72 years into 27': Book by late Fremont man offers inspiration
EPI-743 Clinical Trial begins at UCLA and CHOP
FARA Spokesperson, Kyle Bryant, was honored at the Tampa Bay Lightning game
Altadena and Santa Clarita Women Unite In Fight to Cure Friedreich’s Ataxia
Industry lends muscle to genetic disease
Tennis Channel coverage of Fara's Ace for a Cure w/ John Isner
STATegics, Inc. Announces a New Grant from Friedreich’s Ataxia Research Alliance
FDA Recognizes 30 Heroes Changing Lives of Those with Rare Diseases - FARA President and Co-Founder to be Honored
Counting her Blessings: Islander lives with Friedreich's ataxia
USF Ataxia Research Center announces enrollment for a phase 2B EPI-743 trial in FA patients
Medical Mysteries: Cerebral palsy proves not to be the cause of boy’s decline
John Isner & Kyle Bryant Discuss the Value of Determination & Perseverance
Living the Decision: A Pocket Guide to Cramming 72 years of living into 27.
Genetic Counseling Students Volunteer at Ride Ataxia Benefit
EPI-743 Phase 2B Friedreich Ataxia clinical trial to be initiated
FARA leads the Neuromuscular Community in Important FDA Recommendation
300 take part in Hayden's Hope event
Fundraiser scheduled for Hayden Despenas
Free concert in Queensbury to draw attention to rare disease
Amy Scherzer's Diary: Partying at the RNC, FARA Energy Ball
2012 FARA Energy Ball Video
USF Health to lead new Friedreich's ataxia study
Trike brings thrilling rides for boy with rare disease
James Blake & Kyle Bryant - Confidence in FA Research
Update your FARA Patient Registry Account Today!
FA Symposium at Children's Hospital of Philadelphia Save The Date - Oct 8, 2012
Interview with Kyle Bryant about Ride Ataxia and the Energy Ball
Friedreich's Ataxia Awareness Day is Saturday, May 19th- Meet a Few of the Faces of Friedreich’s Ataxia
St. Catherine’s Annual Jog-A-Thon Supports Research for Friedrich’s Ataxia
Impossible is Nothing.
Junior receives award named in memory of advocate for disabled
Family fights disease through fundraising and Ride Ataxia
North Texas Bike-A-Thon For Neuromuscular Disease
Denton bike riders aim to beat rare disease
Teen's rare disease disconnects brain from nervous system
FARA Press Release - Partnership and Collaboration take promising therapy
Positive Pakistani: Steel wheels
Research on Hearing loss in FA - Tuesday March 27th 7:00pm EST
Speaker challenges students to define themselves
Edison Girl's Rare Disease in Spotlight Feb 29
Perrysburg teenager does not let disease hold him back
Order Papa John's Pizza and Join in the Fight Against a Rare Disease
New Clinical Trial in Friedreich's Ataxia in Italy
Help support the NIH budget Write Congress to express your concerns
Gabe Ford takes anti-bullying message to Thanksgiving Day parade
Good news for all patient families!
Reason to run
Ride Ataxia announces 2011 AAI Grant Recipients
ViroPharma licenses rights from Intellect Neurosciences for product candidate for Friedreich's Ataxia
Fighting the Odds
Faith, Friedreich’s Ataxia in the Heart — Shoot for the Cure
Race for Grace Could Use Your Support
Community Day to Cure FA - Walk and Picnic Sept. 11
Still Dancing by Gabrielle Ford
Fara Energy Ball 2011
Positively Tampa Bay: FARA Energy Ball
STATegics, Inc. announces a grant from FARA to Support it's Program
The Alliance’s 'member spotlight' is currently shining on …
SAVE THE DATE! 4th Annual Friedreich's Ataxia Symposium October 8th, 2011
Gathering lets people with disease know they're not alone
FARA/RepliGen Webinar – Tuesday July, 26th 1:00pm EST
Determined to fight it
FARA President's Letter
EPI-A0001 Improves Neurological Outcome Endpoint in 28-Day Phase 2A Double-Blind Placebo-Controlled Clinical Trial in Friedreich’s Ataxia
FARA Grant Funding Opportunities 2011
FDA Grants Orphan Drug Designation to EPI-743 and Allows Expanded Access in Mitochondrial Diseases Including Friedreich’s Ataxia
Vote for The Ataxian documentary in The Pepsi Refresh Project
Strasbourg FA Scientific Meeting Conference Photos and Thanks
Santhera Presents Positive Data from IONIA Open-Label Extension Study in Friedreich's Ataxia at the Fourth International Friedreich's Ataxia Scientific Conference
4th International Friedreich’s Ataxia Scientific Conference to Convene May 5th-7th 2011
Intellect Neurosciences Files Orphan Drug Application in the United States for its Clinical Candidate OX1 for the Treatment of Friedreich’s Ataxia
Tiffany's Friends fundraiser in the News
Sunshine Ranches Superbowl Party Raises Thousands
Rare Diseases Take Spotlight in Annual Event
The Friedreich’s Ataxia Research Alliance Joins Millions Around the World To Observe Rare Disease Day
FARA receives a 4 star rating from Charity Navigator
21-year-old doesn't let disease get in his way
Neurology Today movie review: The Cake Eaters
FARA is Key Participant in Government Report on Accelerating Rare Disease Research
Wiffle Ball tournament fights disease
DIA/FDA Orphan Drug Designation Workshop Nov 4-5, 2010
4th International Friedreich’s Ataxia Scientific Conference
Fitchburg man says disease won't sidetrack active lifestyle
Symposium participants optimistic about finding first treatment for Friedreich's ataxia
The FARA Energy Ball on Channel 8 in Tampa
Interview with Studio 10 - Kyle Bryant and Ron Bartek discuss the FARA Energy Ball
The Friedreich's Ataxia Research Alliance Announces the 2010 Ataxian Athlete Initiative Grant Recipients
Advances in Ataxia Research Focus of USF-FARA Symposium
Repligen Receives Additional Research Grants to Support Development of HDAC Inhibitors for Friedreich’s Ataxia and Huntington’s Disease
Local hikers take to High Peak for FA
Friedreich's ataxia has no cure, but researchers are working on answers
Third Annual Friedreich's Ataxia Symposium
FARA Annual Report 2009
Student Crowned Miss Wheelchair NH
Kyle Bryant Friedreich’s Ataxia Race Across America RAAM
Me, My Bike, and I - Notes from the RAAM Finish Line
FARA hosts Friedreich's ataxia Cardiac Summit on June 11th in Philadelphia
The Ride Of His Life - Kyle Bryant in Sactown Magazine
Team FARA - Race Across America - on channel 10 news
The 2010 Kyle Bryant Translational Research Award and The Bronya J. Keats Award for International Collaboration in Research on Friedreich's Ataxia
Pharma's Orphans - FARA in Pharmaceutical Executives Magazine
Ride Ataxia Kicked off the 2010 ride series in Tampa - and spoke on NBC Daytime about Ride Ataxia and FARA
Events Across the United States Mark Friedreich's Ataxia Awareness Day
FARA Congratulates Nygel Lenz on Receiving the 2010 Dean's Award from the University of South Florida
Clinical Trial Update - Double-Blind, Randomized, Placebo-Controlled Pilot Study of Varenicline in the Treatment of FA
Billy Tauzin, President and CEO of PhRMA Address at the PhRMA Meeting on March 18, 2010
Teens experience life in wheelchairs
PhRMA Honors Patient Advocates Ron and Raychel Bartek
Demystifying Medicine
FARA Congratulates Melissa Phares, ChairScholar Award Winner
FARA Announces the 2010 Ataxian Athlete Initiative
FDA Expands Commitment to Patients with Rare Diseases
FARA receives Quality of Life grant from Christopher and Dana Reeve Foundation
Ride Ataxia NorCal Press Release
The Outback Steakhouse Pro-Am Teams Up with Ride Ataxia Tampa Bay
Neurology Now - Friedreich's Ataxia
Classmate's disorder leads to school effort
Repligen Corporation F3Q10 (Qtr End 12/31/09) Earnings Call Transcript
Team FARA Races Across America to Raise Awareness for Friedreich's ataxia
Introducing the New FARA Logo
Keith Michael Andrus: 12/21/1985 - 01/22/2010
Penwest Announces Initiation of Phase IIa Clinical Trial of A0001 in Patients with Friedreich's Ataxia
FARA offered access to National Scholarship Program for Students with Disabilities
Wasco Students Take Steps For A Cure
Second Annual Friedreich's Ataxia Research Symposium
$360,000 in Kyle Bryant Translational Research Awards Announced Today
Stars glow in Branford for Friedreich's event
FARA’s First Friends & Allies Award Presented to th e Executive & Creative Team of The Cake Eaters
Repligen Announces Identification of Drug Target for Friedreich’s Ataxia
Outback Steakhouse and Local Non-Profit Ride for a Cure, support clinic at Children's Hospital of Philadelphia
Mayor of the City of Tampa Proclaims September 25 - Ataxia Awareness Day
Family united as kids work to find cure for sister's disease
Forrest Sawyer adds his Voice to Non-Profit Cause
Symposium looks toward cure for ataxias
Penwest Pharmaceuticals (PPCO) Announces Results of Phase Ib Trial of A0001
2009 Kyle Bryant Translational Research Award sponsored by Ride Ataxia, the Friedreich’s Ataxia Research Alliance and the National Ataxia Foundation
Fitness Together Helps Client in Wheelchair Fight Disease with Exercise
New study to examine whether smoking cessation drug Varenicline may benefit adults with Friedreich’s ataxia
Santhera's US Phase III IONIA Trial in Friedreich's Ataxia Misses Primary Endpoint
Research Progress Fuels Preparations for "Friedreich's Ataxia Awareness Day"
Ride Ataxia III - Portland
Cyclist with Rare Neuromuscular Disorder to Arrive in Seattle March 19 Completing 4 Day Cycling Journey
Cyclist with a Rare Neuromuscular Disorder to Begin Third Cycling Journey from Portland
New Film, Directed by Mary Stuart Masterson, Features Kristen Stewart as a Young Woman with the Neuro-degenerative disease Friedreich's ataxia
Fund-raiser to benefit study of boy's disease
Perrysburg Junior High teachers spend day in wheelchairs
Cyclist with Rare Neuromuscular Disorder to Begin Third Cycling Journey
Santhera Enrolls Last Patient in Pivotal US Phase III with SNT-MC17/Idebenone in Friedreich’s Ataxia
Social Security Announces Nationwide Launch of Compassionate Allowances
BGC Partners, Inc. Selects the Friedreich's Ataxia Research Alliance as a Charity Day Recipient
EDS, Employees garner FARA Partner of the Year honor
Alliance Charities, Inc. Introduces a Way to Support Causes in Tough Economic Times
Gill Family Wins FARA a Spot on Jimmie Johnson’s Helmet of Hope To Be Worn During NASCAR's Pepsi 500 on August 31, 2008
$250,000 in Kyle Bryant Translational Research Awards Announced Today
CANADA- FIRST TO APPROVE DRUG IN FRIEDREICH’S ATAXIA
First Human Dose Initiated of Promising New Friedreich’s Ataxia Drug Highlights Effectiveness of New Public-Private Partnership Model
Request for Applications
Congressman Andrews FA Awareness Day Resolution
The Cake Eaters
Vice - President and Chief Executive for Science
'Working for Lindsay' campaign pays off
Cyclists Bring Attention to Disabling Disease -- Friedreich's Ataxia
Cyclist with Rare Neuromuscular Disorder to Arrive in Las Vegas March 27 Following Cross-Country Journey
Ride Ataxia II
Cyclist with Rare Neuromuscular Disorder to Begin Second Cross-Country Journey from Sacramento
EDS Foundation Awards $40,000 Grant to Friedreich's Ataxia Research Alliance
Kyle Bryant $100,000 Award to Australian / UK Collaboration to Test Possible Friedreich's Ataxia Antioxidant Treatment in Mouse Model
Assistance dog provides learning situation for all
Community Champions: EDSers Help Young People Afflicted with Neuromuscular Disease
The Mothers and Daughters of The Cake Eaters
Repligen Licenses Potential Treatment for Friedreich's Ataxia from The Scripps Research Institute
Cross-Country Cyclist with Rare Neuromuscular Disorder to Pedal through Phoenix
International Friedreich's Ataxia Conference at NIH Highlights Promising Research, Clinical Trials and the Importance of Public-Private Partnership
Frank Wootten to Cycle Coast-to-Coast to Raise Awareness and Research Money for His Son's Friedreich's Ataxia
Actress Mary Stuart Masterson to Host Local Friedreich’s Ataxia Fundraiser
Scripps Research Team Reverses Friedreich's Ataxia Defect in Cell Culture
Raytheon Support Group Helps Match Service Dog Shadow with 9-Year-Old Donovan
Friedrich's Ataxia Patient Raising Funds for Research
Friedreich's Ataxia Research Alliance Announces Support from NIH RAID Pilot Program
MDA and FARA to Accelerate Friedreich's Ataxia Research
EDS and RIT Partner to Develop Solution for Friedreich's Ataxia Research
Time for giving
Promising Clinical Trials Fuel Preparations for "Friedreich's Ataxia Awareness Day" — May 20, 2006
Fundraisers party to help Friedreich's Ataxia group
Friedreich's Ataxia Research Alliance (FARA) Awards Edison Pharmaceuticals $3 Million Development Grant
Friedreich's Ataxia Research Alliance (FARA) Joins with MDA and Seek A Miracle in Fighting Friedreich’s Ataxia
LSU Researcher Receives NIH Grant to Study Causes of Friedreich's Ataxia
"Exciting Scientific Advances" Trigger Hope on "Friedreich's Ataxia Awareness Day" — May 21, 2005
Friedreich’s Ataxia Research Alliance Research Grants Reach $2-million Mark
Researcher Targets DNA Replication for Better Understanding of Friedreich’s Ataxia
Explosion of Research Triggers Hope on "Friedreich’s Ataxia Awareness Day" — May 15
All-volunteer IT Coalition Builds Computer Network Critically Needed for Friedreich’s Ataxia Medical Research
Scientists Herald Beginning of the "Treatment Era" for Friedreich's Ataxia
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Scientific News
Funded Research
Safety and feasibility of upper limb cardiopulmonary exercise test in Friedreich ataxia
Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice
Methylated and unmethylated epialleles support variegated epigenetic silencing in Friedreich ataxia
Omaveloxolone: potential new agent for Friedreich ataxia
Hand Dexterity and Pyramidal Dysfunction in Friedreich Ataxia, A Finger Tapping Study
Developing an Instrumented Measure of Upper Limb Function in Friedreich Ataxia
Mitochondrial dysfunction in the development and progression of neurodegenerative diseases
Central Nervous System Therapeutic Targets in Friedreich Ataxia
High Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse Models
The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia
An Overview of the Ferroptosis Hallmarks in Friedreich's Ataxia
Assessment of Disease Progression in Friedreich Ataxia using an Instrumented Self Feeding Activity
Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich's ataxia
A Highly Conserved Iron-Sulfur Cluster Assembly Machinery between Humans and Amoeba Dictyostelium discoideum: The Characterization of Frataxin
Global, multi-stakeholder, consortium launched to study neuroimaging biomarkers for Friedreich Ataxia
Emerging therapies in Friedreich's Ataxia
The Friedreich’s Ataxia Accelerator will apply genomics tools to promote discovery of new treatments
Ataxia: Hope starts with measurement
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Test-retest reliability of the Friedreich's ataxia rating scale
Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density
Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia
Relationship between activity and stability: Design and characterization of stable variants of human frataxin
Mitochondrial Damage and Senescence Phenotype of Cells Derived From a Novel Frataxin G127V Point Mutation Mouse Model of Friedreich's Ataxia
HMTase Inhibitors as a Potential Epigenetic-Based Therapeutic Approach for Friedreich's Ataxia
CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells From Patients With Friedreich's Ataxia
Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus
Neurofilament Light Chain as a Potential Biomarker of Disease Status in Friedreich Ataxia
Primary Proprioceptive Neurons From Human Induced Pluripotent Stem Cells: A Cell Model for Afferent Ataxias
Progress Towards Drug Discovery for Friedreich's Ataxia: Identifying Synthetic Oligonucleotides That More Potently Activate Expression of Human Frataxin Protein
Long-term voluntary running prevents the onset of symptomatic Friedreich's ataxia in mice
The Assessment of Upper Limb Functionality in Friedreich Ataxia via Self-Feeding Activity
Psychometric properties of the Friedreich Ataxia Rating Scale
Correlation of Visual Quality of Life With Clinical and Visual Status in Friedreich Ataxia
Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue
Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines
An Instrumented Measurement Scheme for the Assessment of Upper Limb Function in Individuals with Friedreich Ataxia
Predictors of loss of ambulation in Friedreich's ataxia
Frataxin Structure and Function
Health related quality of life in Friedreich Ataxia in a large heterogeneous cohort
Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE-FRDA study
Longitudinal Increases in Cerebral Brain Activation During Working Memory Performance in Friedreich Ataxia: 24-Month Data from IMAGE-FRDA
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
Age of onset determines intrinsic functional brain architecture in Friedreich ataxia
Electrophysiological evidence for limited progression of the proprioceptive impairment in Friedreich ataxia
Mitochondrial dysfunction in neurons in Friedreich's ataxia
Orphan Drugs In Development For The Treatment Of Friedreich's Ataxia: Focus On Omaveloxolone
Temporal but not spatial dysmetria relates to disease severity in FA
The Structure of the Human ACP-ISD11 Heterodimer
Primary Cultures of Pure Embryonic Dorsal Root Ganglia Sensory Neurons as a New Cellular Model for Friedreich's Ataxia
Changes detected in swallowing function in Friedreich ataxia over 12 months
Excision of the expanded GAA repeats corrects cardiomyopathy phenotypes of iPSC-derived Friedreich's ataxia cardiomyocytes
Folding and Dynamics are Strongly pH-Dependent in a Psychrophile Frataxin
Exploring iron-binding to human frataxin and to selected Friedreich ataxia mutants by means of NMR and EPR spectroscopies
Molecular Mechanisms and Therapeutics for the GAA·TTC Expansion Disease Friedreich Ataxia
New developments in pharmacotherapy for Friedreich ataxia
The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting
Evaluation of antibodies for western blot analysis of frataxin protein isoforms
Evidence for genetically determined degeneration of proprioceptive tracts in Friedreich ataxia
Open label Pilot Study of Oral Methylprednisolone for the Treatment of Patients with Friedreich Ataxia
Altered neocortical tactile but preserved auditory early change detection responses in Friedreich ataxia
Microvascular pathology in Friedreich cardiomyopathy
Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia
Efficient Electroporation of Neuronal Cells Using Synthetic Oligonucleotides: Identifying Duplex RNA and Antisense Oligonucleotide Activators of Human Frataxin Expression
Probing the multifactorial source of hand dysfunction in Friedreich ataxia
Identification of a novel missense mutation in Friedreich's ataxia -FXNW 168R
Randomized, double-blind, placebo-controlled study of interferon-γ 1b in Friedreich Ataxia
Therapeutic Prospects for Friedreich's Ataxia
The Role of Iron in Friedreich's Ataxia: Insights From Studies in Human Tissues and Cellular and Animal Models
Progress in understanding Friedreich's ataxia using human induced pluripotent stem cells
C-Path and FARA announce the launch of the FA Integrated Clinical Database
Ferroptosis as a novel therapeutic target for Friedreich's ataxia
Differences in the determinants of right ventricular and regional left ventricular long-axis dysfunction in Friedreich ataxia
GRP75 overexpression rescues frataxin deficiency and mitochondrial phenotypes in Friedreich Ataxia cellular models
Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures
Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes
Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophysiology
Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells
Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion
Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich's Ataxia Models
Longitudinal analysis of contrast acuity in Friedreich ataxia
Understanding Recent Publication on the Effects of AAV Gene Therapy in a New Mouse Model
Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich's ataxia
Rapid and Complete Reversal of Sensory Ataxia by Gene Therapy in a Novel Model of Friedreich Ataxia
Drosophila melanogaster Models of Friedreich's Ataxia
Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich's ataxia patients
Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia
Impact of Mobility Device Use on Quality of Life in Children With Friedreich Ataxia
Identification of p38 MAPK as a novel therapeutic target for Friedreich's ataxia
GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one
Progress in the treatment of Friedreich ataxia
Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy
Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat
Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia
Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia
Somatic instability of the expanded GAA repeats in Friedreich's ataxia
Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia
C-Path and FARA announce collaborative data aggregation project for Friedreich’s ataxia
Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers
Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia
Can rehabilitation improve the health and well-being in Friedreich's ataxia: a randomized controlled trial?
CRISPR Therapeutics Awarded Grant from FARA to Collaborate with University of Alabama at Birmingham on Gene-edited Treatments for Friedreich’s Ataxia
IARC 2017 Follow Up
Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction
Impact of diabetes in the Friedreich ataxia clinical outcome measures study
Selected missense mutations impair frataxin processing in Friedreich ataxia
Heart and Nervous System Pathology in Compound Heterozygous Friedreich Ataxia
Pharmacological therapeutics in Friedreich Ataxia: The present state
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model
AFAF and FARA invite proposals for research projects that advance drug discovery, development of novel biomarkers or improve clinical outcomes in Friedreich’s ataxia patients
How does performance of the Friedreich Ataxia Functional Composite compare to rating scales?
Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency
Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy
Longitudinal gait and balance decline in Friedreich's Ataxia: A pilot study
Measuring Inhibition and Cognitive Flexibility in Friedreich Ataxia
Cardiac transplantation in Friedreich Ataxia: Extended follow-up
Friedreich Ataxia: Hypoplasia of Spinal Cord and Dorsal Root Ganglia
Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals
Challenges ahead for trials in Friedreich's ataxia
A longitudinal study of the SF-36 version 2 in Friedreich ataxia
Progression of Friedreich ataxia: quantitative characterization over 5 years
Retrotope announces Phase I/II Clinical Trial Results of RT001 in Treatment of Friedreich’s ataxia
Alleviating GAA repeat induced transcriptional silencing of the Friedreich's ataxia gene during somatic cell reprogramming
Friedreich ataxia induced pluripotent stem cell-derived neurons show a cellular phenotype that is corrected by a benzamide HDAC inhibitor
Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts
The significance of intercalated discs in the pathogenesis of Friedreich cardiomyopathy
Deep sequencing of mitochondrial genomes reveals increased mutation load in Friedreich's ataxia
Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration
Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia
Abundance and Significance of Iron, Zinc, Copper, and Calcium in the Hearts of Patients With Friedreich Ataxia
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation
Comorbid Medical Conditions in Friedreich Ataxia: Association With Inflammatory Bowel Disease and Growth Hormone Deficiency
Effects of Genetic Severity on Glucose Homeostasis in Friedreich Ataxia
Using human pluripotent stem cells to study Friedreich ataxia cardiomyopathy
Gastrocnemius and soleus spasticity and muscle length in Friedreich's ataxia
Establishment and Maintenance of Primary Fibroblast Repositories for Rare Diseases-Friedreich's AtaxiaExample
Long-term effect of epoetin alfa on clinical and biochemical markers in friedreich ataxia
Gene transfer of brain derived neurotrophic factor (BDNF) prevents neurodegeneration triggered by frataxin deficiency
Activating frataxin expression by repeat-targeted nucleic acids
Friedreich Ataxia and nephrotic syndrome: a series of two patients
Pathology of Intercalated Discs in Friedreich Cardiomyopathy
FARA Announces Catabasis Pharmaceuticals as the Recipient of the Kyle Bryant Translational Research Award to Evaluate CAT-4001 as a Potential Therapy for Friedreich’s Ataxia
Compound heterozygous FXN mutations and clinical outcome in Friedreich ataxia
Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus
Frataxin levels in peripheral tissue in Friedreich ataxia
Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets
Phenotypic Screening for Friedreich Ataxia Using Random shRNA Selection
Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia
Src inhibitors modulate frataxin protein levels
Delivery of human frataxin genomic DNA locus creates different frataxin isoforms
An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels
Friedreich's ataxia - a case of aberrant transcription termination?
Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells
Excision of expanded GAA repeats alleviates the molecular phenotype of Friedreich's ataxia
A longitudinal study of the Friedreich Ataxia Impact Scale
Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia
Publication for open-label trial of Resveratrol in FA
Iron loading site on the Fe-S cluster assembly scaffold protein is distinct from the active site
Excision of expanded GAA repeats alleviates the molecular phenotype of Friedreich's ataxia
The pathogenesis of cardiomyopathy in friedreich ataxia
A novel GAA repeat expansion-based mouse model of Friedreich ataxia
Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency
Friedreich Ataxia: Failure of GABA-ergic and Glycinergic Synaptic Transmission in the Dentate Nucleus
Gait and Balance in Adults with Friedreich's Ataxia
Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia
Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells
Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron, and requirements for GTP, NADH, and ATP
Consensus clinical management guidelines for Friedreich ataxia
Cellular, Molecular and Functional Characterisation of YAC Transgenic Mouse Models of Friedreich Ataxia
Epigenetic therapy for Friedreich's ataxia
A study of up to 12 years of follow-up of Friedreich ataxia utilising four measurement tools
Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's Ataxia
Mesenchymal Stem Cells Improve Motor Functions and Decrease Neurodegeneration in Ataxic Mice
Therapeutic approaches for the treatment of Friedreich's ataxia
Functional Characterization of Friedreich Ataxia iPS-Derived Neuronal Progenitors and Their Integration in the Adult Brain
MutLα Heterodimers Modify the Molecular Phenotype of Friedreich Ataxia
Epigenetic-based therapies for Friedreich ataxia
Cross-sectional analysis of glucose metabolism in Friedreich Ataxia
R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome
High-Throughput Immunoassay for the Biochemical Diagnosis of Friedreich Ataxia in Dried Blood Spots and Whole Blood
A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds
Trichostatin A Enhances Differentiation of Human Induced Pluripotent Stem Cells to Cardiogenic Cells for Cardiac Tissue Engineering
Insights into the role of oxidative stress in the pathology of Friedreich Ataxia using peroxidation resistant polyunsaturated fatty acids
Friedreich ataxia: metal dysmetabolism in dorsal root ganglia
Analysis of the visual system in Friedreich ataxia
Increased prevalence of sleep-disordered breathing in Friedreich ataxia
Supported Research
Design Therapeutics Launches with $45 Million to Develop a New Class of Disease-Modifying Therapies for Serious Degenerative Disorders
Chondrial Therapeutics Announces Dosing of First Patients in Phase 1 Clinical Program of CTI-1601 for Treatment of Friedreich’s Ataxia
Exicure Announces First Neurological Development Program in Friedreich’s Ataxia and Expands Scientific Advisory Board
Reata Announces Positive Topline Results from the MOXIe Registrational Trial of Omaveloxolone in Patients with Friedreich’s Ataxia
Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
Reata Pharmaceuticals, Inc. Announces Positive Data From Part One of Moxie Trial of Omaveloxolone for Friedreich’s Ataxia
Applying the Retro-Enantio Approach to Obtain a Peptide Capable of Overcoming the Blood-Brain Barrier
Longitudinal Strain in Friedreich Ataxia: A Potential Marker for Early Left Ventricular Dysfunction
Special Issue: 150 Years of Friedreich Ataxia Research
Development of Frataxin Gene Expression Measures for the Evaluation of Experimental Treatments in Friedreich's Ataxia
Rating disease progression of Friedreich's ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes
Common data elements for clinical research in Friedreich's ataxia
A0001 in Friedreich ataxia: Biochemical characterization and effects in a clinical trial
The displacement of frataxin from the mitochondrial cristae correlates with abnormal respiratory supercomplexes formation and bioenergetic defects in cells of Friedreich ataxia patients
The Complex Genetic Landscape of Hereditary Ataxias in Turkey and Implications in Clinical Practice
Retrotope Granted Rare Pediatric Disease Designation from FDA
Auditory Phenotypic Variability in Friedreich's Ataxia Patients
Prognostic value of longitudinal strain and ejection fraction in Friedreich ataxia
Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease
Gauging Gait Disorders with a Method Inspired by Motor Control Theories: A Pilot Study in Friedreich's Ataxia
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich's ataxia fibroblasts
DNA repair pathways are altered in neural cell models of frataxin deficiency
Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging
Efficacy of echocardiography for differential diagnosis of left ventricular hypertrophy: special focus on speckle-tracking longitudinal strain
Friedreich ataxia in COVID-19 time: current impact and future possibilities
LEXEO Therapeutics Launches with $85 Million Series A Financing to Develop Gene Therapies for Rare and Non-Rare Monogenic Diseases
Cardiomyopathy as the first manifestation of Friedreich's ataxia
Effects of Fe 2+/Fe 3+ Binding to Human Frataxin and Its D122Y Variant, as Revealed by Site-Directed Spin Labeling (SDSL) EPR Complemented by Fluorescence and Circular Dichroism Spectroscopies
Efficacy and Tolerability of Interferon Gamma in Treatment of Friedreich's Ataxia: Retrospective Study
Exicure Provides Neuroscience Pipeline Update at Virtual R&D Day
Thioredoxin and Glutaredoxin Systems as Potential Targets for the Development of New Treatments in Friedreich's Ataxia
Minoryx's clinical candidate leriglitazone shows clinical benefit in a proof of concept Phase 2 study in Friedreich's ataxia
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia
Larimar Therapeutics Announcement/Program Update
Molecular Defects in Friedreich's Ataxia: Convergence of Oxidative Stress and Cytoskeletal Abnormalities
Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease
Ferroptosis in Friedreich's Ataxia: A Metal-Induced Neurodegenerative Disease
Analysis of Postural Control in Sitting by Pressure Mapping in Patients with Multiple Sclerosis, Spinal Cord Injury and Friedreich's Ataxia: A Case Series Study
PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia
Sensitivity of Neuroimaging Indicators in Monitoring the Effects of Interferon Gamma Treatment in Friedreich's Ataxia
Effect of Mitochondrial and Cytosolic FXN Isoform Expression on Mitochondrial Dynamics and Metabolism
Electrocardiogram in Friedreich's ataxia: A short-term surrogate endpoint for treatment efficacy
Epicardial ablation for ventricular tachycardia in Freidreich's ataxia cardiomyopathy
Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model
Aerobic Exercises Induce Antioxidant Pathways Activation in Rats
Safety and Efficacy of Omaveloxolone in Friedreich's Ataxia (MOXIe Study)
Clinical Therapeutic Management of Human Mitochondrial Disorders
Longitudinal Study of Cognitive Functioning in Friedreich's Ataxia
Sexual function, intimate relationships and Friedreich ataxia
Clinical Features and Molecular Genetics of Autosomal Recessive Ataxia in the Turkish Population
Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells
Assessment of Ataxia Rating Scales and Cerebellar Functional Tests: Critique and Recommendations
Quantitative Assessment of Friedreich Ataxia through the self-drinking activity
Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis
Mechanistic concepts of iron-sulfur protein biogenesis in Biology
Expanding the genotype-phenotype correlation of childhood sensory polyneuropathy of genetic origin
Loss of mitochondrial localization of human FANCG causes defective FANCJ helicase
Iron-sulfur cluster protein NITROGEN FIXATION S-LIKE 1 and its interactor FRATAXIN function in plant immunity
Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients
Iron-Sulfur Cluster Complex Assembly in the Mitochondria of Arabidopsis thaliana
Molecular and Cellular Substrates for the Friedreich Ataxia. Significance of Contactin Expression and of Antioxidant Administration
HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions
Plasma and red blood cell membrane accretion and pharmacokinetics of RT001 (bis-allylic 11,11-D2-linoleic acid ethyl ester) during long term dosing in patients
Friedreich Ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies
Inherited Cerebellar Ataxias: 5-Year Experience of the Irish National Ataxia Clinic
Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich's ataxia: DNA triplexes and RNA/DNA hybrids
Reata provides update on development of omaveloxolone in FA
R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities
Onset features and time to diagnosis in Friedreich's Ataxia
A Drosophila model of Friedreich Ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine
Antioxidant Defense Mechanisms and its Dysfunctional Regulation in the Mitochondrial Disease, Friedreich's Ataxia
Toward quantitative neuroimaging biomarkers for Friedreich's ataxia at 7 Tesla: Susceptibility mapping, diffusion imaging, R 2 and R 1 relaxometry
Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?
Larimar Therapeutics Announces Dosing of Patients in Third Cohort of Phase 1 SAD Trial of CTI-1601 for Treatment of Friedreich’s Ataxia
Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders
Safety and Efficacy of (+)-Epicatechin in Subjects with Friedreich's Ataxia: A Phase II, Open-Label, Prospective Study
MR imaging and spectroscopy in degenerative ataxias: toward multimodal, multisite, multistage monitoring of neurodegeneration
Cardiolipin-deficient cells have decreased levels of the iron-sulfur biogenesis protein frataxin
Compound heterozygosity for an expanded (GAA) and a (GAAGGA) repeat at FXN locus: from a diagnostic pitfall to potential clues to the pathogenesis of Friedreich ataxia
Trinucleotide Repeat Disorders
Stress-induced Mouse Model of the Cardiac Manifestations of Friedreich's Ataxia Corrected by AAV-mediated Gene Therapy
A Novel Solution-Gated Graphene Transistor Biosensor for Ultrasensitive Detection of Trinucleotide Repeats
New Request For Proposals: Therapeutic window of frataxin
Feasibility and Acceptability of Lee Silverman Voice Treatment in Progressive Ataxias
Treatment of Dilated Cardiomyopathy in a Mouse Model of Friedreich's Ataxia Using N-acetylcysteine and Identification of Alterations in MicroRNA Expression That Could Be Involved in Its Pathogenesis
Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy
Vestibular Impact of Friedreich Ataxia in Early Onset Patients
Cerebellar Cognitive Disorder Parallels Cerebellar Motor Symptoms in Friedreich Ataxia
Significance of NT-proBNP and High-sensitivity Troponin in Friedreich Ataxia
Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis
Chondrial Therapeutics and Zafgen Complete Merger and Begin Operating as Larimar Therapeutics
Making iron-sulfur cluster: structure, regulation and evolution of the bacterial ISC system
Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement
Neurologic Outcomes in Friedreich Ataxia: Study of a Single-Site Cohort
Therapeutic Potential of Stem Cells for Treatment of Neurodegenerative Diseases
ExpansionHunter Denovo: A Computational Method for Locating Known and Novel Repeat Expansions in Short-Read Sequencing Data
Oxidative Stress, a Crossroad Between Rare Diseases and Neurodegeneration
Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis
A Comprehensive Transcriptome Analysis Identifies FXN and BDNF as Novel Targets of miRNAs in Friedreich's Ataxia Patients
An Overview of the Current State and the Future of Ataxia Treatments
Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis
Cofilin dysregulation alters actin turnover in frataxin-deficient neurons
Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia
Frataxin-deficient cardiomyocytes present an altered thiol-redox state which targets actin and pyruvate dehydrogenase
A wearable video-oculography based evaluation of saccades and respective clinical correlates in patients with early onset ataxia
Neurophysiologic intraoperative monitoring (NIOM) in pediatric patients with polyneuropathy
Identification of Frataxin as a regulator of ferroptosis
Inherited Metabolic Diseases and Cardiac Pathology in Adults: Diagnosis and Prevalence in a CardioMetabo Study
Management of Neuroinflammatory Responses to AAV-Mediated Gene Therapies for Neurodegenerative Diseases
On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
The Potential of the Novel NAD+ Supplementing Agent, SNH6, as a Therapeutic Strategy for the Treatment of Friedreich's Ataxia
Ocular Involvement in Friedreich Ataxia Patients and its Relationship with Neurological Disability, a Follow-up Study
The NRF2 Signaling Network Defines Clinical Biomarkers and Therapeutic Opportunity in Friedreich's Ataxia
Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis
Developing an objective evaluating system to quantify the degree of upper limb movement impairment in patients with severe Friedreich's ataxia
NfL and pNfH are increased in Friedreich's ataxia
Safety and Efficacy of Interferon γ in Friedreich's Ataxia
Frataxin deficiency in Friedreich's ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte death and survival
Large-scale contractions of Friedreich's ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability
MDA Awards Venture Philanthropy Funding of More Than $1M to AavantiBio to Develop Gene-Targeting Therapy for Friedreich's Ataxia
Mammalian iron-sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins.
Retrotope Expands its Drug Pipeline with the First Dosing of RT001 in patients with Friedreich’s ataxia (FA)
Genetic Analysis of Hereditary Ataxias in Peru Identifies SCA10 Families with Incomplete Penetrance
Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients
A new tool to determine the cellular metabolic landscape: nanotechnology to the study of Friedreich's ataxia
Neurochemical profiles in hereditary ataxias: A meta-analysis of Magnetic Resonance Spectroscopy studies
Iron Hack - A symposium/hackathon focused on porphyrias, Friedreich's ataxia, and other rare iron-related diseases
Zafgen and Chondrial Therapeutics Announce Definitive Merger Agreement
Effects of tocotrienol supplementation in Friedreich's ataxia: A model of oxidative stress pathology
Friedreich's Ataxia: Case series and the Additive Value of Cardiovascular Magnetic Resonance
Pediatric Neuromuscular Disorders
N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain
Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes
Left ventricular structural and functional changes in Friedreich ataxia - Relationship with body size, sex, age and genetic severity
Global Ataxia Advocacy Organizations Unite to Host International Ataxia Research Conference in Washington, DC
Quantitative Proteomic and Network Analysis of Differentially Expressed Proteins in PBMC of Friedreich's Ataxia (FRDA) Patients
Refinement of protein Fe(II) binding characteristics utilizing a competition assay exploiting small molecule ferrous chelators
Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells
Speech and Language Disorders in Friedreich Ataxia: Highlights on Phenomenology, Assessment, and Therapy
Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion
The first biallelic missense mutation in the FXN gene in a consanguineous Turkish family with Charcot-Marie-Tooth-like phenotype
Targeting NRF2 for the Treatment of Friedreich's Ataxia: A Comparison among Drugs
Cerebellum and cognition in Friedreich ataxia: a voxel-based morphometry and volumetric MRI study
Predictors of Left Ventricular Dysfunction in Friedreich's Ataxia in a 16-Year Observational Study
Induced pluripotent stem cells-derived neurons from patients with Friedreich ataxia exhibit differential sensitivity to resveratrol and nicotinamide
Minoryx Therapeutics receives FDA Orphan Drug Designation for leriglitazone in Friedreich’s Ataxia
SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia
Minoryx Therapeutics completes enrollment in FRAMES phase 2 trial with leriglitazone in Friedreich's Ataxia
Health-related quality of life and depressive symptoms in Friedreich ataxia
Unique roles of iron and zinc binding to the yeast Fe-S cluster scaffold assembly protein "Isu1"
Mechanism of activation of the human cysteine desulfurase complex by frataxin
Two new Pfizer-coauthored studies validate Novoheart’s pioneering human bioengineered heart tissues and chambers for improving drug development
Scoliosis in Patients With Friedreich Ataxia: Results of a Consecutive Prospective Series
Friedreich ataxia- pathogenesis and implications for therapies
The Working Life of People with Degenerative Cerebellar Ataxia
Backbone resonance assignments and secondary structure of the apo-Drosophila melanogaster frataxin homolog (Dfh)
Application of Quantitative Motor Assessments in Friedreich Ataxia and Evaluation of Their Relation to Clinical Measures
Oral mobility reflects rate of progression in advanced Friedreich's ataxia
Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich's Ataxia Neural Stem Cells
Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin
Low frataxin mRNA expression is associated with inflammation and oxidative stress in patients with type 2 diabetes
REGENXBIO Announces New License Agreement with Pfizer for the Treatment of Friedreich's Ataxia Using NAV® AAV9 Vector
Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells
Frequency and Genetic Profile of Compound Heterozygous Friedreich's Ataxia Patients-the Brazilian Experience
FARA Job Posting: Associate Director of Research
Deuterated Polyunsaturated Fatty Acids Reduce Oxidative Stress and Extend the Lifespan of C. elegans
Young Investigators: Call for Abstracts, 12th Annual FA Symposium
p53 Binds Preferentially to Non-B DNA Structures Formed by the Pyrimidine-Rich Strands of GAA·TTC Trinucleotide Repeats Associated with Friedreich's Ataxia
Erythropoietin and Friedreich Ataxia: Time for a Reappraisal?
Peripapillary retinal nerve fibre layer thickness in Friedreich's ataxia: a biomarker for trials?
New Insights into the Hepcidin-Ferroportin Axis and Iron Homeostasis in iPSC-Derived Cardiomyocytes from Friedreich's Ataxia Patient
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Mechanism of frataxin "bypass" in human iron-sulfur cluster biosynthesis with implications for Friedreich's ataxia
StrideBio and Takeda Sign Collaboration and License Agreement to Advance Novel Gene Therapies for Neurological Diseases
Patient reported outcomes in Friedreich's Ataxia after withdrawal from Idebenone
Assessment of cell-free levels of iron and copper in patients with Friedreich's ataxia
Inherited Ataxia and Intrathecal Baclofen for the Treatment of Spasticity and Painful Spasms
The role of robotic gait training and tDCS in Friedrich ataxia rehabilitation: A case report
Minoryx Therapeutics receives approval from Spanish regulatory agency to initiate Phase 2 Study in Friedreich's Ataxia
Guidelines on the diagnosis and management of the progressive ataxias
In Vitro interaction between yeast frataxin and superoxide dismutases: Influence of mitochondrial metals
The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A
Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template
Phosphodiesterase Inhibitors Revert Axonal Dystrophy in Friedreich's Ataxia Mouse Model
Heart disease in Friedreich's ataxia
Neurocrine Biosciences and Voyager Therapeutics Form Strategic Development and Commercialization Collaboration for Parkinson’s Disease and Friedreich’s Ataxia
OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia
Structural and functional characterization of a frataxin from a thermophilic organism
Longitudinal evaluation of iron concentration and atrophy in the dentate nuclei in friedreich ataxia
Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia
Correction of half the cardiomyocytes fully rescue Friedreich Ataxia mitochondrial cardiomyopathy through cell-autonomous mechanisms
Large Interruptions of GAA Repeat Expansion Mutations in Friedreich Ataxia Are Very Rare
Depressive symptoms in Friedreich ataxia
FAST-1 antisense RNA epigenetically alters FXN expression
Rapid and Complete Reversal of Sensory Ataxia by Gene Therapy in a Novel Model of Friedreich Ataxia
Oligonucleotides Hold Promise as a Therapy for Friedreich's Ataxia
Voyager Therapeutics Announces Additional Data at the American Society of Gene and Cell Therapy 2018 Annual Meeting
Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia
Plasma Markers of Neurodegeneration Are Raised in Friedreich's Ataxia
Intraepidermal Nerve Fiber Density in Friedreich's Ataxia
Developmental and Neurodegenerative Damage in Friedreich Ataxia
Corneal Confocal Microscopy: Neurologic Disease Biomarker in Friedreich's Ataxia
Automated functional upper limb evaluation of patients with Friedreich ataxia using serious games rehabilitation exercises
Iron in Friedreich Ataxia: A Central Role in the Pathophysiology or an Epiphenomenon
Functional and Structural Brain Damage in Friedreich's Ataxia
Sudomotor dysfunction is frequent and correlates with disability in Friedreich ataxia
Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag
Test-retest reliability of an instrumented electronic walkway system (GAITRite) for the measurement of spatio-temporal gait parameters in young patients with Friedreich's ataxia
Two funded post-doctoral positions are available in the laboratory of Hélène Puccio at the IGBMC in Strasbourg.
Nonataxia symptoms in Friedreich Ataxia: Report from the Registry of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)
RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation Caused by Intronic Repeat Expansions
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity
PTC Therapeutics to acquire Agilis Biotherapeutics
Young Investigators, Call for Abstracts for the 11th Annual Friedreich's Ataxia Symposium
Impact of Drosophila Models in the Study and Treatment of Friedreich's Ataxia
Autonomic function testing in Friedreich's ataxia
Structural characteristics of the central nervous system in Friedreich ataxia: an in vivo spinal cord and brain MRI study
Cognitive and functional connectivity alterations in Friedreich's ataxia
Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model
The importance of central auditory evaluation in Friedreich's ataxia
Diabetes mellitus in Friedreich Ataxia: A case series of 19 patients from the German-Austrian diabetes mellitus registry
Randomized, clinical trial of RT001: Early signals of efficacy in Friedreich's ataxia
Rapid exhaustion of auditory neural conduction in a prototypical mitochondrial disease, Friedreich ataxia
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts
Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich's Ataxia
Pitfalls in molecular diagnosis of Friedreich ataxia
Bone marrow transplantation stimulates neural repair in Friedreich's ataxia mice
Biophysical characterisation of the recombinant human frataxin precursor
Small RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich's ataxia patients
RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication
Serum uric acid in Friedreich Ataxia
Join Reata WebEx. Get updates on the MOXIe Phase 2 Study
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis
The role of Nrf2 signaling in counteracting neurodegenerative diseases
Effect Of Diazoxide on Friedreich Ataxia Models
Emotion Recognition and Psychological Comorbidity in Friedreich's Ataxia
Friedreich and dominant ataxias: quantitative differences in cerebellar dysfunction measurements
Mitochondrial pore opening and loss of Ca2+ exchanger NCLX levels occur after frataxin depletion
The role of oxidative stress in Friedreich's ataxia
Synthetic transcription elongation factors license transcription across repressive chromatin
Insights on the conformational dynamics of human frataxin through modifications of loop-1
Peripheral Nerve Ultrasound in Friedreich's Ataxia
Personality and Neuropsychological Profiles in Friedreich Ataxia
Agilis Biotherapeutics Announces Orphan Product Designation Approval in Europe for the Treatment of Friedreich Ataxia
Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich's ataxia
Friedreich's ataxia: clinical features, pathogenesis and management
Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich's Ataxia
Reata Announces First Patient Enrolled in Part 2 of MOXIe Study of Omaveloxolone for the Treatment of Friedreich’s Ataxia
Friedreich Ataxia: Developmental Failure of the Dorsal Root Entry Zone
Sustained FXN expression in dorsal root ganglia from a nonreplicative genomic HSV-1 vector
BioMarin Highlights Breadth of Innovative Development Pipeline at R&D Day on Oct 18th in New York
The Subclinical Cardiomyopathy of Friedreich's Ataxia in a Pediatric Population
FDA awards six grants for natural history studies in rare diseases
Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment
Urinary, bowel and sexual symptoms in a cohort of patients with Friedreich's ataxia
Agilis Biotherapeutics Updates on Progress in CNS Gene Therapy Programs
Molecular Alterations in a Mouse Cardiac Model of Friedreich's Ataxia: An Impaired Nrf2 Response Mediated via Up-Regulation of Keap1 and Activation of the Gsk3β Axis
Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice
LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures
Defining the Architecture of the Core Machinery for the Assembly of Fe-S Clusters in Human Mitochondria
Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia
Overexpression of Drosophila frataxin triggers cell death in an iron-dependent manner
Part 2 of the Phase II MOXIe study (RTA 408 or omaveloxolone)
Cerebral Abnormalities in Friedreich Ataxia: A Review
Jupiter Orphan Therapeutics Receives Orphan Drug Designation for its Trans-Resveratrol Product JOTROL for Treatment of Friedreich's Ataxia
FDA Confirms That Use of mFARS as Primary Endpoint in Part 2 of the MOXIe Trial Can Support Approval of Omaveloxolone in Friedreich’s Ataxia
Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia
Chondrial Announces FDA Orphan Drug Designation for CTI-1601, a Novel Investigational Technology for the Treatment of Friedreich's Ataxia
Call for Abstracts - 10th Annual Friedreich’s Ataxia Symposium
Circulating miR-323-3p is a biomarker for cardiomyopathy and an indicator of phenotypic variability in Friedreich's ataxia patients
Cerebral compensation during motor function in Friedreich ataxia: The IMAGE-FRDA study
Structural signature of classical versus late-onset friedreich's ataxia by Multimodality brain MRI
Erythropoietin and small molecule agonists of the tissue-protective erythropoietin receptor increase FXN expression in neuronal cells in vitro and in Fxn-deficient KIKO mice in vivo
Dimethyl Fumarate Mediates Nrf2-dependent Mitochondrial Biogenesis in Mice and Humans
Normalization of timed neuropsychological tests with the PATA rate and nine-hole pegboard tests
Dysphagia in Friedreich Ataxia
Mesenchymal Stem Cell-Derived Factors Restore Function to Human Frataxin-Deficient Cells
Frataxin Deficiency Impairs Mitochondrial Biogenesis in Cells, Mice and Humans
No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells
FARA Job Posting: Research Director
Call For Abstracts - 2nd International Ataxia Research Conference
Visiting FARA Funded Researchers
Rare Disease Day 2017 – Friedreich ataxia: Researchers from Fratagene Therapeutics and the University of Rome “Tor Vergata” identify a new therapeutic target
Call For Abstracts - 2nd International Ataxia Research Conference
E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia
Chondrial Therapeutics Secures Up to $22.6 Million in Series A Financing and Licenses Novel Technology for the Treatment of Friedreich’s Ataxia
Newly Funded FARA Grants
STEADFAST Background for the Friedreich's Ataxia community
Cytokine therapy-mediated neuroprotection in a Friedreich's ataxia mouse model
Deletion of the GAA repeats from the human frataxin gene using the CRISPR-Cas9 system in YG8R-derived cells and mouse models of Friedreich Ataxia
Mitochondrial capacity, muscle endurance & low energy in friedreich ataxia
Liver Growth Factor (LGF) Upregulates Frataxin Protein Expression and Reduces Oxidative Stress in Friedreich's Ataxia Transgenic Mice
Horizon Pharma plc Announces Topline Results from Phase 3 Study of ACTIMMUNE® (interferon gamma-1b) in Friedreich's Ataxia
Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting
Save The Date - 2017 International Ataxia Research Conference
Heterologous mitochondrial targeting sequences can deliver functional proteins into mitochondria
Cognition in Friedreich's ataxia: a behavioral and multimodal imaging study
Functional and Gait Assessment in Children and Adolescents Affected by Friedreich's Ataxia: A One-Year Longitudinal Study
Pharmacological treatments for Friedreich ataxia
Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia
Serum versus Imaging Biomarkers in Friedreich Ataxia to Indicate Left Ventricular Remodeling and Outcomes
Frataxin silencing alters microtubule stability in motor neurons: implications for Friedreich's Ataxia
Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery
Cerebral and cerebellar grey matter atrophy in Friedreich ataxia: the IMAGE-FRDA study
Voice in Friedreich Ataxia
Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia
Agilis Biotherapeutics Announces FDA Orphan Drug Designation for the Treatment of Friedreich’s Ataxia (FA)
Pfizer aims to become industry leader in gene therapy with acquisition of Bamboo Therapeutics, Inc.
9th Annual Friedreich’s Ataxia Symposium – 2016 CHOP/FARA – Call For Abstracts
The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion
Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease
Interferon gamma may improve cardiac function in Friedreich's ataxia cardiomyopathy
Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU
Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy
Vestibulo-ocular reflex dynamics with head-impulses discriminates spinocerebellar ataxias types 1, 2 and 3 and Friedreich ataxia
Oxidative Stress and altered lipid metabolism in Friedreich ataxia
US FDA Grants Orphan Drug Designation for Retrotope’s RT001 in the treatment of Friedreich’s ataxia
Reata Pharmaceuticals, Inc. Announces Pricing of Initial Public Offering
Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia
Plasma circulating cell-free mitochondrial DNA in the assessment of Friedreich's ataxia
Horizon Pharma plc to Acquire Worldwide Rights to Interferon Gamma-1b From Boehringer Ingelheim International GmbH
Meeting Notice: FARA's Biomarker Meeting, Sept 16, 2016
Job Opportunity: Postdoctoral Fellow Position open at University of Alabama at Birmingham
Horizon Pharma plc Completes Target Enrollment of 90 Patients for Phase 3 Trial of ACTIMMUNE(R) (interferon gamma-1b) for the Treatment of People With Friedreich's Ataxia
Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia
Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia
Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich ataxia
Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice
Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia
The Structure of the Complex Between Yeast Frataxin and Ferrochelatase: Characterization and pre-Steady StateReaction of Ferrous Iron Delivery and Heme Synthesis
Clinical Experience With Deferiprone Treatment for Friedreich Ataxia
Iron chelation in the treatment of neurodegenerative diseases
Tissue atrophy and elevated iron concentration in the extrapyramidal motor system in Friedreich ataxia: the IMAGE-FRDA study
Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34
Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: The Sub-Complex Formed by the Iron Donor, Yfh1, and the Scaffold, Isu1
Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor
Combined Cerebellar Proton MR Spectroscopy and DWI Study of Patients with Friedreich's Ataxia
Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich's ataxia
Retrotope advances RT001 in clinical trials to treat Friedreich’s ataxia
Avalanche Biotechnologies and Annapurna Therapeutics announce proposed merger
Emerging therapies in Friedreich's ataxia
Nonneurological Involvement in Late-Onset Friedreich Ataxia (LOFA): Exploring the Phenotypes
Update on the STEADFAST study
Chondrial Therapeutics Announces Development Milestone
Jupiter Orphan Therapeutics, Inc. Enters into a Global Licensing Agreement with Murdoch Childrens Research Institute
FARA Grant Program Update
Annapurna Therapeutics to Collaborate with Weill Cornell Medicine on Gene-Therapy Portfolio
Longitudinal magnetic resonance imaging study shows progressive pyramidal and callosal damage in Friedreich's ataxia
Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin
Analyzing the Effects of a G137V Mutation in the FXN Gene
GIFT-1, a phase IIa clinical trial to test the safety and efficacy of IFNγ administration in FRDA patients
Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA
Retrotope RT0001 Clinical Trial Update
Reata RTA 408 Clinical Trial Update
Retrotope announces opening of second clinical trial site for enrollment in Friedreich’s ataxia clinical trial.
Funding Announcement: Clinical Trial Readiness for Rare Neurological and Neuromuscular Diseases (U01)
A 22-Year Follow-up Study of Long-term Cardiac Outcome and Predictors of Survival in Friedreich Ataxia
FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia
Delayed-onset Friedreich's ataxia revisited
Evidence for chromosome fragility at the frataxin locus in Friedreich ataxia
Friedreich ataxia in Norway - an epidemiological, molecular and clinical study
Investigation of mitochondrial DNA variations among Indian Friedreich's ataxia (FRDA) patients
Key Patent Granted For AAVLife’s Gene-Therapy Program to Treat Cardiomyopathy in Friedreich’s Ataxia
New funding opportunity announced by NINDS, NIH for neuroscience investigators. LOIs are due Sept 6, 2015 RFA-NS-16-001
Call for Abstracts due Friday, Aug. 7th, 2015
Mitigation of Myocardial Ischemia-Reperfusion Injury via HIF-1α-Frataxin Signalling
The Role of Frataxin in Doxorubicin Mediated Cardiac Hypertrophy
Regional Cerebral Disease Progression in Friedreich's Ataxia: A Longitudinal Diffusion Tensor Imaging Study
Gene Expression Profile in Peripheral Blood Cells of Friedreich Ataxia Patients
TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia
Ultra-structural hair alterations in Friedreich's ataxia: A scanning electron microscopic investigation
GAA triplet-repeats cause nucleosome depletion in human genome
Identification of telomere dysfunction in FA
Cardioprotective HIF-1α-frataxin signaling
New cellular model to follow FA development in time-resolved way
Novel aberrant genetic and epigenetic events in FA
Cardiomyopathy in FA: New biomarker for staging cardiac involvement
Turning E. coli into a Frataxin-Dependent Organism
Turning Yeast into a Frataxin-Independent Organism
Switching Frataxin Function by Single Amino Acid Substitution within [Fe-S] Cluster Assembly Scaffold
Sensorimotor skills in Mouse mutants frataxin-deficient in muscle
Iron-sulfur Assembly Complex Catalyzes [2Fe-2S] Clusters on ISCU2
Interaction of frataxin with IscU of Fe-S clusters
Mitoferrin modulates iron toxicity in a drosophila model of Friedreich´s ataxia
Diffusion tensor imaging and tract-based spatial statistics analysis in Friedreich's ataxia patients
Structural characterization of metal binding to a cold-adapted frataxin
Abnormal Cochlear Potentials in Friedreich's Ataxia Point to Disordered Synchrony of Auditory Nerve Fiber Activity
Selective observation of the disordered import signal of a globular protein by in-cell NMR: The example of frataxins
Sensorimotor skills in Fxn KO/Mck mutants deficient for frataxin in muscle
GSK Discovery Fast Track Challenge opening soon
Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the complex IscS/IscU to promote iron-sulfur cluster assembly
Milestones in Friedreich ataxia: more than a century and still learning
Very late-onset friedreich ataxia with laryngeal dystonia
International Congress on "Friedreich's Ataxia & DNA Structure in Health and Disease" to be held April 11-13, 2015 at the All India Institute of Medical Sciences, New Delhi, India
Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells
Genome-Engineering Tools to Establish Accurate Reporter Cell Lines That Enable Identification of Therapeutic Strategies to Treat Friedreich's Ataxia
Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols
"Both Sides of the Wheelchair": The Views of Inpiduals with, and Parents of Inpiduals with Friedreich Ataxia Regarding Pre-symptomatic Testing of Minors
Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data
Friedreich's ataxia: the European consortium
Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity
Poor fluorodeoxyglucose uptake in myocardial viability study in nondiabetic Friedreich's ataxia patient
Monitoring Cardiac Function During Idebenone Therapy in Friedreich's Ataxia
p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron
Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes
Cerebellar pathology in Friedreich's ataxia: Atrophied dentate nuclei with normal iron content
Open-label pilot study of interferon gamma-1b in Friedreich ataxia
An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models
Probing the Kinetic Stabilities of Friedreich's Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform
Comparing speech characteristics in spinocerebellar ataxias type 3 and type 6 with Friedreich ataxia
Nasality in Friedreich ataxia
Overlapping Binding Sites of the Frataxin Homologue Assembly Factor
A longitudinal VBM study monitoring treatment with erythropoietin in patients with Friedreich ataxia
Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery
Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein
Overlapping Binding Sites of the Frataxin Homologue Assembly Factor and the Heat Shock Protein 70 Transfer Factor on the Isu Iron-sulfur Cluster Scaffold Protein
Frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry
A 7-year-old girl with hypertrophic cardiomyopathy and progressive scoliosis
Deferiprone in Friedreich ataxia: A 6-Month randomized controlled trial
Epigenetic promoter silencing in Friedreich ataxia is dependent on repeat length
Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia
Post-Doctoral Fellowship available for research on Friedreich's Ataxia
Human Frataxin Activates Fe-S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry
Sensitivity of Spatiotemporal Gait Parameters in Measuring Disease Severity in Friedreich Ataxia
The role of frataxin in fission yeast iron metabolism: Implications for Friedreich's ataxia
Myelin paucity of the superior cerebellar peduncle in inpiduals with Friedreich ataxia: an MRI magnetization transfer imaging study
The Alteration of the C-terminal Region of Human Frataxin Distorts its Structural Dynamics and Function
Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation
Low Bone Mineral Density in Friedreich Ataxia
Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism
Atypical Friedreich ataxia in patients with FXN p.R165P point mutation or comorbid hemochromatosis
Nicotinamide in Friedreich's ataxia: useful or not?
Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study
Dentate nuclei T2 relaxometry is a reliable neuroimaging marker in Friedreich's ataxia
Pathophysiogical and therapeutic progress in Friedreich ataxia
Cell and gene therapy for Friedreich ataxia - progress to date
Saccade reprogramming in Friedreich ataxia reveals impairments in the cognitive control of saccadic eye movement
Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism
Altered Nucleosome Positioning at the Transcription Start Site and Deficient Transcriptional Initiation in Friedreich Ataxia
Frataxin Silencing Inactivates Mitochondrial Complex I in NSC34 Motoneuronal Cells and Alters Glutathione Homeostasis
Gene Expression Profiling of Mitochondrial Oxidative Phosphorylation (OXPHOS) Complex I in Friedreich Ataxia(FRDA) Patients
Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia
Rescue of the Friedreich Ataxia Knockout Mutation in Transgenic Mice Containing an FXN-EGFP Genomic Reporter
Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease.
Generation and Characterisation of Friedreich Ataxia YG8R Mouse Fibroblast and Neural Stem Cell Models
Edison Shedding Light on Energy Production in Diseased Cells
Safety and tolerability of carbamylated erythropoietin in Friedreich's ataxia
Molecular and clinical investigation of Iranian patients with Friedreich ataxia
Kinetics of folding of frataxin
Foundation-industry relationships - a new business model joint-venture philanthropy in therapy development
Usefulness of frataxin immunoassays for the diagnosis of Friedreich ataxia
Beyond loss of frataxin: the complex molecular pathology of Friedreich ataxia
Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria
The kinetics of folding of frataxin
HFE p.C282Y heterozygosity is associated with earlier disease onset in Friedreich ataxia
Dysphagia and swallowing-related quality of life in Friedreich ataxia
Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells
Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein
Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites
Frataxin mRNA Isoforms in FRDA Patients and Normal Subjects: Effect of Tocotrienol Supplementation
Methylene blue rescues heart defects in a Drosophila model of Friedreich's ataxia
Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1
Cognitive Deficits In Friedreich Ataxia Correlate with Micro-structural Changes in Dentatorubral Tract
EFACTS - European Friedreich's Ataxia Consortium for Translational Studies
FARA, Ataxia UK and GoFAR invite proposals for projects to develop biomarkers by non-invasive approaches
White Matter Changes in Patients with Friedreich Ataxia after Treatment with Erythropoietin
Friedreich Ataxia Patient Tissues Exhibit Increased 5-Hydroxymethylcytosine Modification and Decreased CTCF Binding at the FXN Locus
A Potential New Therapeutic Approach for Friedreich Ataxia: Induction of Frataxin Expression With TALE Proteins
Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia
Quantitative profiling and identification of differentially expressed plasma proteins in friedreich's ataxia
Induced Pluripotent Stem Cells from Friedreich Ataxia Patients Fail to Upregulate Frataxin During In Vitro Differentiation to Peripheral Sensory Neurons
Ferredoxin Competes with Bacterial Frataxin in Binding to the Desulfurase IscS
His86 from the N-Terminus of Frataxin Coordinates Iron and Is Required for Fe-S Cluster Synthesis
Friedreich Ataxia: Executive Control Is Related to Disease Onset and GAA Repeat Length
Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia
The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin
Neurodegeneration in Friedreich's Ataxia: From Defective Frataxin to Oxidative Stress
The Gait Variability Index: A new way to quantify fluctuation magnitude of spatiotemporal parameters during gait
Diagnosis and Genetic Counseling for Friedreich's Ataxia: A time for consideration of TP-PCR in an Indian Setup
Perceived Effectiveness and Barriers to Physical Therapy Services for Families and Children With Friedreich Ataxia
Stem Cells from Wildtype and Friedreich's Ataxia Mice Present Similar Neuroprotective Properties in Dorsal Root Ganglia Cells
Triple therapy with deferiprone, idebenone and riboflavin in Friedreich's ataxia - open-label trial
Fatigue is frequent and multifactorial in Friedreich's ataxia
Radial diffusivity in the cerebellar peduncles correlates with clinical severity in Friedreich ataxia
Triple Therapy with Darbepoetin Alfa, Idebenone, and Riboflavin in Friedreich's Ataxia: an Open-Label Trial
High-dose thiamine improves the symptoms of Friedreich's ataxia
Downstream MMR processing contributes to GAA·TTC repeat expansion
Cardiac remodeling of intercalated discs in Friedreich's ataxia
Therapeutic Strategies in Friedreich's ataxia
Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons
Cerebello-cerebral connectivity deficits in Friedreich ataxia
Mitochondrial Diseases of the Brain
Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies
Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia
Assessment of upper limb function in young Friedreich ataxia patients compared to control subjects using a new three-dimensional kinematic protocol
Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy
The Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in Oligomerization
Bilateral cochlear implantation in Friedreich's ataxia: A case study
A Dynamic Model of Proteins that Form the Initial Iron-Sulfur Cluster Biogenesis Machinery in Yeast Mitochondria
Friedreich's ataxia-associated GAA repeats induce replication-fork reversal and unusual molecular junctions
Impact of Friedreich's Ataxia on health-care resource utilization in the United Kingdom and Germany
Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection
The Reciprocal Cerebellar Circuitry in Human Hereditary Ataxia
Complexes between two GAA Repeats within DNA introduced into Cos-1 cells
Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by Vitamin B3
A Dynamic Model of the Proteins that Form the Initial Iron-Sulfur Cluster Biogenesis Machinery in Yeast Mitochondria
Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia
Very late-onset Friedreich ataxia: later than life expectancy?
Cognition in Late-Onset Friedreich Ataxia
Pharmacological Screening Using an FXN-EGFP Cellular Genomic Reporter Assay for the Therapy of Friedreich Ataxia
Friedreich ataxia: neuropathology revised
Genetic Variations Creating MicroRNA Target Sites in the FXN 3′-UTR Affect Frataxin Expression in Friedreich Ataxia
Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model
Friedreich Ataxia: Dysarthria Profile and Clinical Data
7th International Conference on Iron-Sulfur Cluster Biogenesis and Regulation May 20-24, 2013
Missense Mutations Linked to Friedreich Ataxia Have Different but Synergistic Effects on Mitochondrial Frataxin Isoforms
Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly
Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans
Friedreich's ataxia with retained reflexes: a phenotype and genotype correlation
Substantia Nigra Echogenicity in Friedreich's Ataxia Patients
Clinical use of frataxin measurement in a patient with a novel deletion in the FXN gene
Synthesis and Biological Activities of N-(3-Carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and Analogues
Genomic deletions and point mutations induced in Saccharomyces cerevisiae by the trinucleotide repeats (GAA*TTC) associated with Friedreich's ataxia
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia
Can telomere shortening in human peripheral blood leukocytes serve as a disease biomarker of Friedreich's Ataxia?
Induced pluripotent stem cell derived neurons and cardiomyocytes as a model for mitochondrial defects in Friedreich's ataxia
Role of DNA Polymerases in Repeat-Mediated Genome Instability
Cells Lacking Pfh1, a Fission Yeast Homolog of Mammalian Frataxin, Display Constitutive Activation of the Iron Starvation Response
Neuroanatomical Correlates of Depression in Friedreich's Ataxia: a Voxel-Based Morphometry Study
R- and S-Equol have equivalent cytoprotective effects in Friedreich's Ataxia
Letter by Peverill Regarding Article, "The Heart in Friedreich Ataxia: Definition of Cardiomyopathy, Disease Severity, and Correlation With Neurological Symptoms"
Pms2 Suppresses Large Expansions of the (GAA·TTC)(n) Sequence in Neuronal Tissues
Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
Auditory pathway changes mirror overall disease progress in individuals with Friedreich ataxia
Relation of Cytosolic Iron Excess to Cardiomyopathy of Friedreich's Ataxia
Binaural Speech Processing in Individuals with Auditory Neuropathy
Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells
EPI-743 Reverses the Progression of the Pediatric Mitochondrial Disease- Genetically Defined Leigh Syndrome
Heterotrifunctional chemical crosslinking mass spectrometry confirms physical interaction between human frataxin and ISU
Management and therapy for cardiomyopathy in Friedreich's ataxia
Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection
Skeletal muscle involvement in friedreich ataxia and potential effects of recombinant human erythropoietin administration on muscle regeneration and neovascularization
Unanswered Questions in Friedreich Ataxia
Human Mesenchymal Stem Cells Increase Anti-oxidant Defences in Cells Derived from Patients with Friedreich's Ataxia
Role of mismatch repair enzymes in GAA-TTC triplet-repeat expansion in Friedreich's ataxia induced pluripotent stem cells (iPSCs)
Therapeutic Developments in Friedreich Ataxia
miR-886-3p Levels Are Elevated in Friedreich Ataxia
Rationale for the Development of 2-Aminobenzamide Histone Deacetylase Inhibitors as Therapeutics for Friedreich Ataxia
Cardiomyopathy in Friedreich Ataxia: Clinical Findings and Research
A functional MRI study of motor dysfunction in Friedreich's Ataxia
DNA triplex structures in neurodegenerative disorder, Friedreich's ataxia
DNA mismatch repair complex MutSbeta promotes GAA•TTC repeat expansion in human cells
Auditory Processing Deficits in Children With Friedreich Ataxia
Friedreich Ataxia Clinical Outcome Measures: Natural History Evaluation in 410 Participants
Clinical Monitoring in a Patient With Friedreich Ataxia and Osteogenic Sarcoma
Cross-Sectional Analysis of Electrocardiograms in a Large Heterogeneous Cohort of Friedreich Ataxia Subjects
Friedreich Ataxia: New Pathways
Cardiac Transplantation in Friedreich Ataxia
Clinical Features of Friedreich Ataxia
Novel Diagnostic Paradigms for Friedreich Ataxia
Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich's ataxia
Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells
Complete FXN Deletion in a Patient with Friedreich's Ataxia
Longitudinal change in dysarthria associated with Friedreich ataxia: a potential clinical endpoint
Elevation of serum cardiac troponin I in a cross-sectional cohort of asymptomatic subjects with Friedreich ataxia
Ultrasound-guided nerve blocks in the Charcot-Marie-Tooth disease and Friedreich's ataxia
TALE proteins induced the expression of the frataxin gene
Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus
Spinal Cord Atrophy Correlates with Disability in Friedreich's Ataxia
Human adipose stem cell-conditioned medium increases survival of Friedreich's ataxia cells submitted to oxidative stress
Decreased functional brain activation in Friedreich ataxia using the Simon effect task
Scoliosis in patients with Friedreich's ataxia
Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich's Ataxia Skin Fibroblasts
Abstracts to be presented at the American Academy of Neurology April 21-28
Retrospective study of the effects of inpatient rehabilitation on improving and maintaining functional independence in people with Friedreich ataxia
Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model
Cardiac Dysfunction Exacerbated by Endocrinopathies in Friedreich Ataxia: A Case Series
Is Friedreich ataxia an epigenetic disorder?
Epigenetics, epidemiology and mitochondrial DNA diseases
Erythropoietin in Friedreich ataxia: No effect on frataxin in a randomized controlled trial
Exonic Deletions of FXN and Early-Onset Friedreich Ataxia
Friedreich's Ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase
Selecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts
Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease
Understanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular models
EDITORIAL: Cardiomyopathy in Friedreich's Ataxia: Exemplifying the Challenges Faced by the Cardiologists in the Management of Rare Diseases
Cognition in Friedreich Ataxia
The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model
Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells
Differentiating profiles of speech impairments in Friedreich's ataxia: a perceptual and instrumental approach
Effects of Friedreich's ataxia GAA repeats on DNA replication in mammalian cells
Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia
FXN methylation predicts expression and clinical outcome in friedreich ataxia (article)
Use of an Adaptive Study Design in Single Ascending-Dose Pharmacokinetics of A0001 (α-Tocopherylquinone) in Healthy Male Subjects
Substantia nigra hypoechogenicity in friedreich ataxia
The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells
HSC20 interacts with Frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis
A gene expression phenotype in lymphocytes from friedreich ataxia patients
A TAT-Frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's Ataxia mouse model
Ophthalmic features of Friedreich ataxia
Exploring frataxin function
Hepatic mitochondrial dysfunction in Friedreich Ataxia
Primary and Secondary Drug Screening Assays for Friedreich Ataxia
Changes in mitochondrial glutathione levels and protein thiol oxidation in Δyfh1 yeast cells and the lymphoblasts of patients with Friedreich ataxia
MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias
Analysis of Echocardiograms in a Large Heterogeneous Cohort of Patients With Friedreich Ataxia
Annual change in Friedreich's ataxia evaluated by the scale for the assessment and rating of ataxia (SARA) is independent of disease severity
The effects of idebenone on mitochondrial bioenergetics
Specific Alterations of Carbohydrate Metabolism Are Associated With Hepatocarcinogenesis in Mitochondrially Impaired Mice
Oligomerization Propensity and Flexibility of Yeast Frataxin Studied by X-ray Crystallography and Small-Angle X-ray Scattering
Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells
Friedreich's ataxia: the vicious circle hypothesis revisited
Initial Experience in the Treatment of Inherited Mitochondrial Disease with EPI-743
Mesenchymal stem cells restore frataxin expression and increase hydrogen peroxide scavenging enzymes in friedreich ataxia fibroblasts
Mutation in Fe-S scaffold Isu bypasses frataxin deletion
PEP-1-Frataxin Significantly Increases Cell Proliferation and Neuroblast Differentiation by Reducing Lipid Peroxidation in the Mouse Dentate Gyrus
The scale for the assessment and rating of ataxia correlates with dysarthria assessment in Friedreich's ataxia
The role of CyaY in iron sulfur cluster assembly on the E. coli IscU scaffold protein
A novel deletion-insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype
Friedreich's Ataxia: a review from a cardiology perspective
The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases
The Fitts task reveals impairments in planning and online control of movement in Friedreich ataxia: reduced cerebellar-cortico connectivity?
Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia
Structure-function analysis of Friedreich's ataxia mutants reveals determinants for frataxin binding and activation of the Fe-S assembly complex
Rapamycin reduces oxidative stress in frataxin-deficient yeast cells
Articulatory Kinematics in the Dysarthria Associated with Friedreich's Ataxia
Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases
Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological & developmental levels
Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levels
Long Range Regulation of Human FXN Gene Expression
Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia
Neurodegeneration in friedreich's ataxia is associated with a mixed activation pattern of the brain. A fMRI study
Friedreich's ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex
Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia
Gait Pattern in Inherited Cerebellar Ataxias
Differential Expression of PGC-1alpha and Metabolic Sensors Suggest Age-Dependent Induction of Mitochondrial Biogenesis in Friedreich Ataxia Fibroblasts
Mortality in Friedreich Ataxia
The cerebellar component of Friedreich's ataxia
Utilisation of Advance Motor Information is Impaired in Friedreich Ataxia
In children with Friedreich ataxia, muscle and ataxia parameters are associated
The Heart in Friedreich's Ataxia: Basic Findings and Clinical Implications
Effects of Erythropoietin on Frataxin Levels and Mitochondrial Function in Friedreich Ataxia - a Dose-Response Trial
Silencing of frataxin gene expression triggers a p53 dependent apoptosis in human neuron-like cells
Early Changes in Left Ventricular Long-Axis Function in Friedreich Ataxia: Relation with the FXN Gene Mutation and Cardiac Structural Change
Altered Zinc Transport Disrupts Mitochondrial Protien Processing/Import In Fragile X-Associated Tremor/Ataxia Syndrome
Idebenone Induces Apoptotic Cell Death in the Human Dopaminergic Neuroblastoma SHSY-5Y Cells
Silencing of frataxin gene expression triggers p53-dependent apoptosis in human neuron-like cells
Friedreich's ataxia: Past, present and future
Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector
NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels
Detection of interruptions in the GAA trinucleotide repeat expansion in the FXN gene of Friedreich ataxia
A combined nucleic Acid and protein analysis in friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design
Brain diffusion-weighted imaging in Friedreich's ataxia
Cardiomyopathy of Friedreich's Ataxia: Use of Mouse Models to Understand Human Disease and Guide Therapeutic Development
Frataxin participates to the hypoxia-induced response in tumors
Quantification of Circulating Plasma DNA in Friedreich's Ataxia and Spinocerebellar Ataxia Types 2 and 12
Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
Impaired myocardial perfusion reserve & fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome
Impaired inhibition of prepotent motor tendencies in Friedreich ataxia demonstrated by the Simon interference task
Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex
The Mitochondrial Connection in Auditory Neuropathy
Divalent counterion-induced condensation of triple-strand DNA
Friedreich's Ataxia (GAA)(n)-(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae
Iron-dependent functions of mitochondria-relation to neurodegeneration
Blood cells from Friedreich ataxia patients harbor frataxin deficiency without a loss of mitochondrial function
Friedreich's ataxia: Pathology, pathogenesis, and molecular genetics
Role of transcript & interplay between transcription and replication in triplet-repeat instability in mammalian cells
Preventing the ubiquitin/proteasome-dependent degradation of frataxin, the protein defective in Friedreich's Ataxia
2010 FARA Scientific News
Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients
Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome
Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich's Ataxia: A New Synthetic Route
The Neuropathology of Late-Onset Friedreich's Ataxia
Axial diffusivity is increased in the degenerating superior cerebellar peduncles of Friedreich's ataxia
Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells
Activation of mitochondrial energy metabolism protects against cardiac failure
Feasibility of Implantable Cardioverter Defibrillator Treatment in Five Patients With Familial Friedreich's Ataxia-A Case Series
Superior Cerebellar Peduncle Atrophy in Friedreich's Ataxia Correlates with Disease Symptoms
The Test of Everyday Attention Reveals Significant Sustained Volitional Attention and Working Memory Deficits in Friedreich Ataxia
Whole-body vibration alters blood flow velocity and neuromuscular activity in Friedreich's ataxia
Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit
Spectral measures of the effects of Friedreich's ataxia on speech
Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA·TTC Triplet Repeat Instability
Getting to the core of repeat expansions by cell reprogramming
Exploration of transitional life events in individuals with Friedreich ataxia: Implications for genetic counseling
Electrophysiology of Respiratory Chain Complexes and ADP/ATP Exchanger in Native Mitochondrial Membranes
Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assembly
Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly
Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex
Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich's Ataxia
Restless Legs and Substantia Nigra Hypoechogenicity are Common Features in Friedreich's Ataxia
Successful treatment of auditory perceptual disorder in individuals with Friedreich ataxia
Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells
Current and emerging treatment options in the management of Friedreich ataxia
The Friedreich's Ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals
Molecular Details of the Yeast Frataxin-Isu1 Interaction during Mitochondrial Fe-S Cluster Assembly
Protective effects of transduced PEP-1-Frataxin protein on oxidative stress-induced neuronal cell death
Protocol proposal for Friedreich ataxia molecular diagnosis using fluorescent and triplet repeat primed polymerase chain reaction
1H MR Spectroscopy in Friedreich's Ataxia and Ataxia with Oculomotor Apraxia Type 2
Defects in Mitochondrial Axonal Transport and Membrane Potential without Increased Reactive Oxygen Species Production in a Drosophila Model of Friedreich Ataxia
Prospects for the use of artificial chromosomes and minichromosome-like episomes in gene therapy
Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria
Expression of Human Frataxin Is Regulated by Transcription Factors SRF and TFAP2
A Phase 3, Double-blind, Placebo-Controlled Trial of Idebenone in Friedreich Ataxia
Exercise Capacity and Idebenone Intervention in Children and Adolescents With Friedreich Ataxia
A rapid, noninvasive immunoassay for frataxin: Utility in assessment of Friedreich ataxia
Evaluation of neuropsychological functions in patients with Friedreich ataxia before and after cognitive therapy
Transposon Tn7 Preferentially Inserts into GAA-TTC Triplet Repeats under Conditions Conducive to Y-R-Y Triplex Formation
Frataxin & mitochondrial Fe-S cluster biogenesis
Frataxin and mitochondrial Fe-S cluster biogenesis
Variations of frataxin protein levels in normal individuals
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
Human iron-sulfur cluster assembly, cellular iron homeostasis and disease
Analysis of the factors influencing the cardiac phenotype in Friedreich's ataxia
Ocular Motor Fixation Deficits in Friedreich Ataxia
Altered lipid metabolism in a Drosophila model of Friedreich's ataxia
Carbamylated erythropoietin increases frataxin independent from the erythropoietin receptor
Nitric oxide & frataxin: two players contributing to maintain cellular iron homeostasis
Dysarthria in Friedreich's Ataxia: A Perceptual Analysis
Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation
Understanding the molecular mechanisms of Friedreich Ataxia to develop therapeutic approaches
Influence of Genetic Factors on Left Ventricular Structure and Function in Friedreich's Ataxia
Therapeutic use of coenzyme Q(10) and coenzyme Q(10)-related compounds and formulations
Intermediate-dose idebenone and quality of life in Friedreich ataxia
Health-related quality of life in children with Friedreich ataxia
Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation
North and South Indian Populations Share a Common Ancestral Origin of Friedreich's Ataxia but Vary in Age of GAA Repeat Expansion
PGC-1alpha Down-Regulation Affects the Antioxidant Response in Friedreich's Ataxia
Pathology and pathogenesis of sensory neuropathy in Friedreich's ataxia
Friedreich ataxia presenting as sudden cardiac death in childhood: Clinical, genetic and pathological correlation, with implications for genetic testing and counselling
Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question
Evidence that yeast frataxin is not an iron storage protein In Vivo
Prevalence of interatrial block in patients with Friedreich's Ataxia
A role for p53 in mitochondrial stress response control of longevity in C. elegans
Automatic method of pause measurement for normal and dysarthric speech
Atypical, perhaps under-recognized? An unusual phenotype of Friedreich ataxia
FRIEDREICH'S ATAXIA: MOLECULAR MECHANISMS, REDOX CONSIDERATIONS AND THERAPEUTIC OPPORTUNITIES
Frataxin, a molecule of mystery: trading stability for function in its iron-binding site
Flavin Adenine Dinucleotide Rescues the Phenotype of Frataxin Deficiency
Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model
A high throughput electrochemiluminescence assay for the quantification of frataxin protein levels
Altered Gene Expression and DNA Damage in Peripheral Blood Cells from Friedreich''s Ataxia Patients: Cellular Model of Pathology
Measuring the rate of progression in Friedreich ataxia: Implications for clinical trial design
Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin
2009 FARA Scientific News
Iron binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region
Clinical measures of dysarthria in Friedreich Ataxia
The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich's ataxia
Yeast frataxin mutants display decreased superoxide dismutase activities crucial to promote protein oxidative damage
Impairment in motor reprogramming in Friedreich ataxia reflecting possible cerebellar dysfunction
Epigenetic Silencing in Friedreich Ataxia Is Associated with Depletion of CTCF (CCCTC-Binding Factor) and Antisense Transcription
Progressive GAA·TTC Repeat Expansion in Human Cell Lines
Auditory Perception in Individuals with Friedreich's Ataxia
Frataxin interacts with Isu1 through a conserved tryptophan in its ß-sheet
Subclinical Myocardial Ischemia Without LV Hypertrophy in Friedreich's Ataxia
The N-terminus of mature human frataxin is intrinsically unfolded
A comparison of three measures of upper limb function in Friedreich ataxia
Characterizing gait, locomotor status, and disease severity in children and adolescents with Friedreich ataxia
Diverse effects in Friedreich's ataxia place PGC-1alpha center-stage
Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing
Friedreich's ataxia: Oxidative stress and cytoskeletal abnormalities
Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise
The dorsal root ganglion in Friedreich's ataxia
Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen.
Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant
The first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxia
Frataxin deficiency induces schwann cell inflammation and death.
Comparison of three clinical rating scales in Friedreich ataxia (FRDA)
Nitric oxide and frataxin: two players contributing to maintain cellular iron homeostasis
Subjective Improvement in Proprioception in 2 Patients With Atypical Friedreich Ataxia Treated With Varenicline (Chantix)
Large-scale expansions of Friedreich's ataxia GAA repeats in yeast
Novel antibody-based strategies for the rapid diagnosis of mitochondrial disease and dysfunction.
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPAR{gamma} pathway as a therapeutic target in Friedreich's ataxia.
Friedreich's ataxia impact scale: A new measure striving to provide the flexibility required by today's studies.
PNA binding and its effect on in vitro transcription in friedreich's ataxia triplet repeats.
Diagnosis and treatment of Friedreich ataxia: a European perspective.
Peptide nucleic acid (PNA) binding and its effect on in vitro transcription in friedreich's ataxia triplet repeats.
Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS.
A combined voxel-based morphometry and (1)H-MRS study in patients with Friedreich's ataxia.
Complex I and ATP content deficiency in lymphocytes from Friedreich's ataxia.
Pharmacotherapy for friedreich ataxia.
Integration of functional bacterial artificial chromosomes into human cord blood-derived multipotent stem cells.
Friedreich's Ataxia: From the (GAA)( n ) Repeat Mediated Silencing to New Promising Molecules for Therapy.
Overexpression of the yeast frataxin homolog (Yfh1): contrasting effects on iron-sulfur cluster assembly, heme synthesis and resistance to oxidative stress.
Impaired nuclear Nrf2 translocation undermines the oxidative stress response in friedreich ataxia.
Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins.
Idebenone in Friedreich's ataxia
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography
The in vivo mitochondrial two-step maturation of human frataxin
The longitudinal course of cardiomyopathy in Friedreich's ataxia during childhood
DNA methylation in intron 1 of the frataxin gene is related to GAA repeat length and age of onset in Friedreich’s ataxia patients
Urinary isoprostanes in Friedreich ataxia: lack of correlation with disease features
The MCK mouse heart model of Friedreich's ataxia
Drosophila Frataxin: An Iron Chaperone during Cellular Fe–S Cluster Bioassembly
Influence of Friedreich Ataxia GAA Noncoding Repeat Expansions on Pre-mRNA Processing
Recombinant human erythropoietin increases frataxin protein expression without increasing mRNA expression
Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis
Health related quality of life measures in Friedreich Ataxia
Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia
Deferiprone targets aconitase: implication for Friedreich's ataxia treatment
Dynamics, stability and iron-binding activity of frataxin clinical mutants
Speech perception ability in individuals with Friedreich ataxia
A cytosolic iron chaperone that delivers iron to ferritin
Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers
Novel, complex interruptions of the GAA repeat in small, expanded alleles of two affected siblings with late-onset Friedreich ataxia
Ancestral roles of eukaryotic frataxin
Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich's ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class
Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia
Antioxidant use in Friedreich ataxia
HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model
Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer
Orthopedic shoes improve gait in Friedreich's ataxia: a clinical and quantified case study
Friedreich's ataxia and scoliosis: the experience at two institutions
Proteomic analysis of hearts from frataxin knockout mice
Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, Isu
Brain white matter tracts degeneration in Friedreich ataxia
The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues
The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin
Repair of DNA double-strand breaks within the (GAA•TTC)n sequence results in frequent deletion of the triplet-repeat sequence
Phosphorus-31 two-dimensional chemical shift imaging in the myocardium of patients with late onset of Friedreich ataxia
Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila
Drug Insight: antioxidant therapy in inherited ataxias
Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications
Brain structural damage in Friedreich's ataxia
Vestibular, saccadic and fixation abnormalities in genetically confirmed Friedreich ataxia
Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins
Idebenone treatment in paediatric and adult patients with Friedreich ataxia: long-term follow-up
DNA triplexes and Friedreich ataxia
Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia
Call for Patients with Friedreich’s Ataxia
Targeting the gene in Friedreich Ataxia
Santhera Announces Start of US Phase III Clinical Trial
Mortality in Friedreich's Ataxia
Results Announced Phase I/II Study of Deferiprone
Moonlighting Enzyme Linked To Neurodegenerative Disease
Santhera Updates Development Strategy
NIH and Santhera Announce Positive Results of Study with SNT-MC17
Health: When Cells Stop Working
A Molecule That Binds GAA-TCC Triplet Repeat DNA Increases Frataxin Protein in Patient Cells
Edison Pharmaceuticals Announces FDA Grants EPI-A0001
Idebenone Phase II Trial Reaches Midpoint at National Institutes of Health
Austrian Lab Supported by FARA Publishes Exciting Findings
Santhera starts European Phase III Study with its Lead Compound SNT-MC17 (idebenone) in Friedreich’s Ataxia
Santhera and the NIH Collaborate to Evaluate SNT-MC17 in FA
NINDS Recruiting Patients for Phase 2 Idebenone Study
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Inspection
Maintenance Ride
Successful Day!
Team Photo
Blog Post 09
Kyle Resting
Nugget Send Off!
Oceanside
Still Driving
We are on our way to Oceanside!
Anxious
Preparations
Team FARA: More News Coverage!
Getting Started
Weather
Whatever it takes
Blog Posting Strategy
Send Off Celebration!
Team FARA on the News!
Live GPS Tracking!
Fluid
Radio Promo
Team FARA Jerseys
Catrike
Hitch Rider
TeamFARA on Good Day Sacramento
Party to Pardee, WIldflower, & Hincapie
Less Than 7
Everything Has Its Place - Gearing Up
Team FARA: Update
Documentary
In Memory of Jack Baumstark
Promotions
Ultra FARAthon!
Team Photo Shoot
Team Photo
Inspiration
About FARA
About Friedreich's ataxia
Meet the Team
RAAM Facts and Tidbits
RAAM FAQ's
About RAAM
Team FARA Sponsorship Opportunities
Team FARA: How YOU Can Help
The RAAM Route
Just passed the halfway mark!
Kansas, we have a problem
RideAtaxia Blog
Strong Partnership Funds the 2019 Ataxian Athlete Initiative (AAI) for People with Ataxia
rideATAXIA Dallas 2019 Dedicated to Sam Brown
2018 Woodstock and rideATAXIA Chicago
2018 rideATAXIA Chicago - Alex Fielding
Cyclists ride around Channahon area to raise money to cure rare disease
My 1st rideATAXIA Experience
rideATAXIA NorCal 2018 dedicated to Matt Rupel
rideATAXIA Quarterly News
2018 Ataxian Athlete Initiative Applications
rideATAXIA Dallas 2018
2018 rideATAXIA SoCal
2017 rideATAXIA Orlando
rideATAXIA SoCal 2018 Dedicated to the Memory of Chelsea Lane
2017 AAI Grant Recipient
The ride of their lives - Ride to Cure FA raises money for rare genetic disease
rideATAXIA Europe- Le Peloton de L’Espoir
rideATAXIA Dallas 2017
rideATAXIA raises over $1 Million in 2016
rideATAXIA Orlando 2016
rideATAXIA Chicago 2016
Ataxian Athlete Initiative Announces 2016 Recipients
2016 rideATAXIA NorCal
rideATAXIA Atlanta 2016
rideATAXIA Dallas 2016
It's All About the FAmily
rideATAXIA Chicago 2015
Ataxian Athlete Initiative Announces 2015 Recipients
2015 rideATAXIA NorCal
A Guide to Beginning Your Search For Adaptive Cycling Equipment
Ride Ataxia Philly Promo Videos
Ride Ataxia funded research. MRI biomarker study at UMN
2014 Ataxian Athlete Initiative Recipients
The Rupeleton Rides Strong Again
NorCal 2014 dedicated to Lee Mitchell
Maximizing Our Impact - Ride Ataxia Relocation; Portland to Seattle
Ride Ataxia 2013 Reflection
Ride Ataxia Remembers Garrett Timbie
Announcing the 2013 Ataxian Athlete Initiative Grant Recipients
Ataxian Athlete Initiative Now Accepting Applications for 2013 Grant Program
Rider Profile: Mark
Rider Profile: Emily
Announcing the 2012 AAI Recipients
Ride Ataxia 2013 Dates
At NorCal 2012 We Ride For Phillip
Shanna Armstrong Joins The Team!
Ride Ataxia Exceeds $1 Million In Funded Research
Ride Ataxia Orlando
Registration is open for Ride Ataxia Philadelphia 2011
Multiply Your Vote with Power Votes
Vote for The Ataxian documentary in The Pepsi Refresh Project
Discounts for NorCal riders!
Jerseys To Honor Phillip
Ride Ataxia NorCal - Dedicated to the Life of Phillip Bennett
Ride Ataxia Dallas - Everything is bigger in Texas!
NorCal 2011 Registration & Fundraising
Brilliant Heart Research
7th Annual Catrike Rally
Top Fundraisers
Ride Ataxia Southern California - Sunsets and Research
Ride Ataxia Philadelphia - A Huge Success!
Teammates in the news
Team FARA on the News!
Inspiration
NorCal Review
Radio Promo
NorCal
Tampa Bay Effort on the News!
Ride Ataxia Listed on Top 50 Walk/Bike/Run Events
Amendment to the 2010 Ataxian Athlete Initiative
2010 Ataxian Athlete Initiative
NorCal Jersey
Radio Blog
Front Page
Ultra FARAthon!
Two New Rides!
Neurology Now!
The Art of Cycling In The Rain
Keith Michael Andrus: 12/21/1985 - 1/22/2010
FA Cardiac Study
Research Study at Dupont Childrens Hospital
Penwest
Blake and Dan
Progression: A balancing act.
FARA West
Edison
rideATAXIA: Philly Review
Success in Philly!
Ride Eve
Publicity
Three days left
Interview With WPHL-17
Made It
Travel Prep
Linda
Valuable Cardboard Box
More Packing
Ride Ataxia Research Funds
Toastmasters
Packing
The Hindsight Years
Production
Speech to Speech
Brianne's Story
Today is my Birthday (actually it ended about 20 minutes ago)
Recovery
rideATAXIA: Every Day in October
Friendly Reminder
Ride Philly Registration
Full Speed Ahead!
USF Symposium
Time Trial
Teammate Intro: DIEGO
Trike Commute!
Little Man, Huge Heart
Presentation
Visualization
Scientists
Ride Ataxia Philly
Training Program
New Trike!
Research!
2009 AAI
Dr. Perlman
Evan's Walk
My New Sport
Training For Next Year
Reflection
Morning Show
Victory!
Triumph
COLD!
Weather and Bridges
'Twas The Night Before
On The Road
Track Us LIVE!
Educate and Enable
Train in the Rain
Skiing!
Training
Ride Ataxia on PBS
Don't Let Cold Weather Slow You Down!
Announcement!
In The News
Ataxian Athlete Initiative
About Ride Ataxia
Kyle's Story
RAIII Registration is NOW OPEN!
Foxy's Fall Century
DE:TERMINENCE
Peregrine Bike Works
International Ataxia Awareness Day '08
Cyclebration
Dream Hope Believe
Around The Lake
Bow Flex
Pay Off
Outback Charity Golf Tournament
Water Skiing
The Berserker
F.A.I.T.H. and Sky ping
Press
Research Funds
rideATAXIA: Linda's Blog
We Made It!
Nearing the Finish Line
Downhill
Climb
Blur
Days 4 and 5
Long Day
Tail Wind
Good Weather, Good People
CPR
Brown and Caldwell
Skiing with DSUSA
Press - Radio Interview
Update
Fun, Outreach, Training
Team Training
Truckee Fundraiser
Train in the rain
New Teammates
Training
Meet The Team: Spinner
Meet the Team: Tess
Meet The Team: Kyle
Participant Information
Ride Ataxia Around The World
Ataxia UK
Planning
Downloads
Support
Ride Ataxia Around the World
NAF Board Meeting
Tour de Cure
Preparations for Vegas
Ride Ataxia II
Success!
More to come!
We Made It!
8 Days and 450 miles ago we started riding in Baton Rouge
Gettin' There
New Orleans
The Italian
rideATAXIA: Louisiana
Uncle Steve Chimes In
The last few miles in Texas
Busy, busy, busy
New Teammates
Yesterday we took off from Ozona Texas
Compilation
Lost and Found
Quick Update
Feb 10, 2007
Shout Out to Phoenix, AZ
Superbowl Sunday
Celebrity blogger. Andy Smith
Salame Sandwich
Bottomless Bookseller
rideATAXIA: Joy and Misery
Testing the nerves
Freeways Up and Down
Dream Weekend
Coming Down to the Wire
In the Garage
Getting Closer To Go-Time
Freezing
Back in the saddle again
ACARM
Slacker
Publicity
Slump
To The City
Foxy's Century
Harsh Ride
B-Day
Road Rash
Lots of Riding
International Ataxia Awareness Day
Lots Going On....
Trek to Work
Some of the Many Reasons
Ride Ataxia Events: Golf Tournament
First Post
Saturday Ride
Memorials
Kevin Dock
Alexandre Bouchard
Starla Ann Brannon-Price
Brenda Laurette Harrison
Loran Mackenzie Martin
Chelsea Davidson
Becca Van Schoick
Karen James
Melissa Fox
Kristen Frey
Eric Christiansen
Joseph Williams
Karye Willard
Chelsea Lane
Aaron Kittel
Keith Andrus
Janice DeSaw
Thomas Barnett
Nick
Benjamin Orth
Kevin Maher
Meet the Ambassadors
Sean Sommerville
Jennifer Gasner
Elizabeth Bowen
Noah Griffith
Marina Deszo
Breaunna Hoffman
Elvis Trompf
Megan Leeper
Keith O’Brien
Andy Sorter
Morgan Talevich
Kyle Waterman
Kelly Barendt
Chris Meyer
Xhesika Peza
Kailey Newcity
Camila Primavesi
Carli Hook Hanson
Natache Iamaya
Madelyn Frederick
Brendan Halverson
Justin Bolinger
Carly Magnuson
Antônio Maranhão Calmon
Jakob Mitterhauser
Mary Nadon Scott
Tricia Herman-Maul
Dillon Head
Kyle Bryant
Brittany Sommerfield
Scarlett Drews
Allison Bouchard
Shandra Trantham
Gabrielle Angioelli
Allison Dana
Ashlea Smith
Morgan Layton
Chelsea Conley
Vlad Ayriyan
Jacob Ferguson
Matt Lafleur
Nygel Lenz
Sam Bridgman
RJ Mercure
Noelle Bouchard
Mary Bircher
Mandy Davis
Jacob Tompkins
Christin Haun
Casey Kasselder
Alex Fielding
Lealan LaRoche Sims
Jamie Plourde
Tom Trovinger
Robbi Van Schoick
Erin O'Neil
Jean Walsh
Andrea Kiess
Clinical Trials
Clinical Trials - Active - Enrolling
Exercise/NAD+ study at CHOP & Penn
PTC-743: MOVE-FA Study
Instrumented Data Exchange for Ataxia (IDEA study)
Burke Institute - Seated Exercise Study
Characterization of the Cardiac Phenotype of Friedreich’s Ataxia
Clinical Outcome Measures in Friedreich’s Ataxia: a natural history study
Idebenone 2008 Phase 3 Follow-Up Study through CHOP and UCLA
Idebenone 2005-06 Phase 2 Follow-Up Study through CHOP
Call for Patients with Friedreich ataxia with upcoming surgical procedure or existing tissue
Neurological Measures of Progression in Children with FA
Friedreich Ataxia - Clinical Outcome Measures
Mitochondrial Disease Participants Needed for New Research Study at CHOP and HUP
Biomarkers in FA
Clinical Trials - Active - Enrollment Closed
The Friedreich’s Ataxia Health Index Study (FA-HI)
CLIN-1601-102 - Larimar Therapeutics Phase I study of CTI-1601, a frataxin replacement therapy
Retrotope RT001-006 Phase 2/3 trial for protection against oxidative damage in the central nervous system
Methods of measuring neuropathy study - University of Rochester
Part 2 of the Phase II MOXIe study (RTA 408 or omaveloxolone)
Magnetic Resonance Imaging (MRI) Muscle Phenotyping in Mitochondrial Disease
Clinical Trials - Completed
BioMarin Pharmaceutical & Sanguine Biosciences -Biomarker Research Study
Phase 2 study of TAK-831 (Takeda)
Cohort 9, MOXIe, Phase 2 Study of RTA 408
A Study of the Safety and Effectiveness of (+) Epicatechin for Treating Patients with Friedreich's Ataxia
A study of walking and balance in Friedreich's Ataxia
Weill Cornell Study of Cardiomyopathy
Call for Patients with Friedreich ataxia Brain Imaging Study
University of Rochester announces FA Study
Glycemic Index in Mitochondrial Disease
Retrotope Annouces a Study of RT001 in Patients with Friedreich’s Ataxia
Cardiac MRI & Biomarkers in Friedreich's ataxia
Exercise in Friedreich's ataxia
Horizon's Actimmune Phase 3 Trial
University of Minnesota MRI Study
EPI-743 in FA Point Mutations
Newcastle Imaging Study
Shire's SHP622 Phase 1 Study (formerly VP-20629)
Cardiovascular Effects of Acetyl-L-Carnitine
Clinical Trials
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