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FARAFARA Cure FA

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols

Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the formation of a persulfide intermediate on NFS1.

Read More: Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols


About the Author

Jen Farmer

Jen Farmer

Executive Director

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