Investigating spinal sensory-motor circuit pathology in two mouse models of FA

This project will investigate how Friedreich’s ataxia affects spinal sensory-motor circuits that help control movement and coordination. Using two mouse models of FA, the study will map changes in spinal interneurons, which are nerve cells that relay signals between sensory input and motor control pathways. These circuits are highly conserved across mammals and are important for normal walking and balance. By examining how neuropathology develops in these circuits over time, the research aims to identify anatomical and functional changes that could serve as benchmarks for future therapies, including gene therapy approaches that restore frataxin expression in spinal sensory-motor pathways. This work will help improve understanding of how FA affects the nervous system and guide the development of treatments that target early disease mechanisms.