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GAA triplet-repeats cause nucleosome depletion in human genome

Genomics. 2015 Jun 20. pii: S0888-7543(15)30014-8. doi: 10.1016/j.ygeno.2015.06.010. [Epub ahead of print]
Zhao H1, Xing Y2, Liu G2, Chen P3, Zhao X2, Li G4, Cai L5

Although there have been many investigations into how trinucleotide repeats affect nucleosome formation and local chromatin structure, the nucleosome positioning of GAA triplet-repeats in the human genome has remained elusive. In this work, the nucleosome occupancy around GAA triplet-repeats across the human genome was computed statistically. The results showed a nucleosome-depleted region in the vicinity of GAA triplet-repeats in activated and resting CD4+ T cells.

Read More: GAA triplet-repeats cause nucleosome depletion in the human genome






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