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FARAFARA Cure FA

Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers

Friedreich’s Ataxia (FA) is an inherited neurodegenerative disease caused by reduction in levels of the mitochondrial protein frataxin. Currently there are no simple, reliable methods to accurately measure the concentrations of frataxin protein. We designed a lateral-flow immunoassay that quantifies frataxin protein levels in a variety of sample materials. Using recombinant frataxin we evaluated the accuracy and reproducibility of the assay. The assay measured recombinant human frataxin concentrations between 40 and 4000 pg/test or approximately 0.1 – 10 nM of sample. The intra and inter-assay error was < 10% throughout the working range. To evaluate clinical utility of the assay we used genetically defined lymphoblastoid cells derived from FA patients, FA carriers and controls.

Read More: Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers

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Jen Farmer

Jen Farmer

Executive Director

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