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FARAFARA Cure FA

Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria

Frataxin is a conserved mitochondrial protein, and deficiency underlies the neurodegenerative disease Friedreich's ataxia. Frataxin interacts with the core machinery for Fe-S cluster assembly in mitochondria. Recently we reported that in frataxin-deleted yeast strains, a spontaneously occurring mutation in one of two genes encoding redundant Isu scaffold proteins, bypassed the mutant phenotypes.

Read More: Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria


About the Author

Jen Farmer

Jen Farmer

Executive Director

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