The N-terminus of frataxin and its role in FRDA

The major function of frataxin is thought to be in synthesis of iron sulfur clusters. However, the unusual features of FA patients who have mutations other than GAA repeats suggest that frataxin may have other functions. In this work, Dr Lynch and his collaborators will examine cells and animals to determine if other functions of frataxin exist, whether they reflect specific parts of frataxin, and whether treatments can be derived based on these novel functions.