Am J Physiol Heart Circ Physiol. 2015 Jun 12:ajpheart.00875.2014. doi: 10.1152/ajpheart.00875.2014. [Epub ahead of print]
Nanayakkara G1, Alasmari A1, Mouli S1, Eldoumani H1, Quindry JC1, McGinnis G1, Fu X1, Berlin A1, Peters B1, Zhong J1, Amin RH2.
Previous studies have demonstrated the protective signaling of Hypoxia Inducible Factor -1 alpha (HIF-1α) against ischemia/ reperfusion (IR) injury in the heart. In this study, we provide further evidence for a cardioprotective mechanism by HIF-1α against IR injury exerted via the mitochondrial protein frataxin, which regulates mitochondrial iron-sulfur (Fe-S) cluster formation. The disruption of frataxin has been found to induce mitochondrial iron overload and subsequent reactive oxygen species (ROS) production. We observed that frataxin expression is elevated in mice hearts subjected to IR injury, and this response was blunted in cardiac specific HIF-1α knockout (KO) mice.
Read More: Cardioprotective HIF-1α-frataxin signaling against ischemia-reperfusion injury